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Affinity Based Protein Profiling of Fendiline Photoprobe in A. Baumannii

ABSTRACT: Competitive Affinity Based Protein Profiling of a Fendiline Photoprobe in A. Baumannii

INSTRUMENT(S):

ORGANISM(S): Acinetobacter Baumannii (strain Atcc 17978 / Cip 53.77 / Lmg 1025 / Ncdc Kc755 / 5377)

TISSUE(S): Cell Culture

SUBMITTER: Carter Brzezinski

LAB HEAD: Stephan Sieber

PROVIDER: PXD056737 | Pride | 2025-12-15

REPOSITORIES: Pride

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			Action	DRS
	20240322_CB_AB-ABPP_1-4xC.raw	Raw
	20240322_CB_AB-ABPP_1-8xC.raw	Raw
	20240322_CB_AB-ABPP_1D.raw	Raw
	20240322_CB_AB-ABPP_1P-.raw	Raw
	20240322_CB_AB-ABPP_1P.raw	Raw

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Publications

Repurposing a drug to punish carbapenem-resistant <i>Acinetobacter baumannii</i>.

Colquhoun Jennifer M JM Brzezinski Carter U CU Ji Andrew A Marotta Julianna J Elsen Franziska A V FAV Bonomo Robert A RA May Kerrie L KL Sieber Stephan A SA Grabowicz Marcin M Wuest William M WM Rather Philip N PN

Proceedings of the National Academy of Sciences of the United States of America 20250610 24

The OXA β-lactamases in <i>Acinetobacter baumannii</i> represent a primary mechanism for resistance to the carbapenems, a class of antibiotics that represent a last line for treatment. In a screen of an U.S. Food and Drug Administration (FDA)-approved drug library, we identified fendiline, a calcium channel blocker, had significantly more antimicrobial activity against OXA-23 expressing cells. Genetic and proteomic studies revealed that fendiline inhibited the essential lipoprotein trafficking p ...[more]

PMID: 40493197

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