Dataset Information

Integral membrane proteome of adult mouse brain and other organs

ABSTRACT: LC-MS/MS analysis with label-free quantification was used to determine the expression levels of ion transporters, particularly those involved in Ca2+ homeostasis

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spleen, Heart, Brain, Skeletal Muscle, Intestine, Lung, Liver, Urinary Bladder, Kidney

SUBMITTER: Alexander Haupt

LAB HEAD: Prof. Dr. Bernd Fakler

PROVIDER: PXD060109 | Pride | 2025-08-25

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	wt-mouse-bladder-membrane.dat	Other
	wt-mouse-bladder-membrane.mgf	Mgf
	wt-mouse-bladder-membrane.mzId	Mzid
	wt-mouse-bladder-membrane.raw	Raw
	wt-mouse-cerebellum-membrane.dat	Other

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Publications

Ca<sup>2+</sup>-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range.

Constantin Cristina E CE Schmidt Barbara B Schwarz Yvonne Y Harada Harumi H Kollewe Astrid A Müller Catrin S CS Henrich Sebastian S Gaal Botond B Kulik Akos A Bruns Dieter D Schulte Uwe U Rieger Heiko H Fakler Bernd B

Nature communications 20250820 1

Ca2+-ATPases in the plasma membrane extrude Ca2+ ions from the cytosol to the extracellular space thereby terminating Ca2+-signals and controlling Ca2+-homeostasis in any type of cell. Recently, these Ca2+-pumps have been identified as protein complexes of the transporting subunits PMCAs1-4 and the single-span membrane proteins Neuroplastin (NPTN) or Basigin that are obligatory for efficient trafficking of the pump complexes to the surface membrane. Quantitative investigation of the pumping velo ...[more]

PMID: 40835599

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