Dataset Information

Proteomic analysis on the underlying mechanisms of PoTX-induced nerve injury

ABSTRACT: Proteomic analysis on the underlying mechanisms of PoTX-induced nerve injury

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Neutrophil

DISEASE(S): Brain Glioblastoma Multiforme,Brain Cancer

SUBMITTER: Zirui Lv

LAB HEAD: Lv Zi Rui

PROVIDER: PXD060121 | Pride | 2025-07-21

REPOSITORIES: Pride

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Publications

Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function.

Lü Zirui Z Dai Xiandong X Xu Jianjie J Zhu Mu M Chen Bo B Guo Yongbiao Y Gao Zhenhua Z Meng Fanhua F

Scientific reports 20250716 1

Poneratoxin (PoTX) is a 25-residue peptide derived from the venom of bullet ant, Paraponera clavata, recognized for its potent activation of Na<sub>V</sub> channel and pain-inducing effects in murine models. In this study, for the first time, we conducted the evaluation of the excitotoxicity of PoTX and performed an in-depth analysis of transcriptomics and proteomics in vitro to elucidate its impact on the nervous system and underlying pharmacological mechanisms. Our results demonstrated that Po ...[more]

PMID: 40670556

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			Action	DRS
	20240829_173912_sp_MJ20240709210_PP20240726578.sne	Other
	Hg13LZR_B1_1.raw	Raw
	Hg13LZR_B2_2.raw	Raw
	Hg13LZR_B3_3.raw	Raw
	Hg13LZR_H1_7.raw	Raw