Proteomics

Dataset Information

0

Molecular analysis of brain tumour models


ABSTRACT: Pilocytic astrocytomas and other paediatric low-grade gliomas (pLGGs) are often considered single-pathway diseases due to the predominance of MAPK/ERK pathway alterations observed in these patients. However, emerging evidence suggests that the MAPK/ERK interacts within a complex signalling network that drives the distinct phenotypes of these tumours. To investigate how these signalling pathways intersect across multiple molecular levels, we have conducted multi-omics analysis of a set of in vitro pLGG models developed by Dr Pratiti Bandopadyay and colleagues at the Dana Farber Cancer Institute, USA, using immortalised H9 neural stem cells engineered to carry the critical BRAF or FGFR driver alterations. The proteomic and phosphoproteomic data are included here.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell

DISEASE(S): Low Grade Glioma

SUBMITTER: Denise Sheer  

LAB HEAD: Professor Pedro R Cutillas

PROVIDER: PXD060246 | Pride | 2025-05-14

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F002812.dat Other
F002812.mzid Mzid
F002813.dat Other
F002813.mzid Mzid
F002815.dat Other
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