Dataset Information
RAS-p110α signalling pathway in macrophages and its impact on both the initiation and resolution of inflammation
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Bone Marrow, Macrophage
DISEASE(S): Inflammation
SUBMITTER: 
Vinothini Rajeeve
LAB HEAD: Professor Pedro R. Cutillas
PROVIDER: PXD057794 | Pride | 2025-04-28
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| E_s1.RAW | Raw | |||
| E_s1.RAW.-1.mgf | Mgf | |||
| E_s10.RAW | Raw | |||
| E_s10.RAW.-1.mgf | Mgf | |||
| E_s10R.RAW | Raw |
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Publications
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
eLife 20250424
Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological processes and tumourigenesis, regulates two vital aspects of the inflammatory response in macrophages: the initial monocyte movement and later-stage lysosomal function. Disrupting this pathway, either in a mouse model or through drug intervention, hampers the in ...[more]
