Dataset Information

Identification of STN1 interactiome in response to DNA damage in pancreatic cancer cells

ABSTRACT: STN1 is known to play a critical role in DNA damage response, however, the mechanisms by which this is performed, specifically in the context of pancreatic cancer are not well understood. Here we studied the changes in STN1 interactome in control and in the response to DNA-damage causing stimuli.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreatic Ductal Cell, Cell Culture

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Krystine Mansfield

LAB HEAD: Patrick Pirrotte

PROVIDER: PXD060475 | Pride | 2025-10-13

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	141_0001_01A_R_SampleARep1FrA_06AUG21_CELL_HUM_ECL_0002_01AN_60MIN_MNM_RS_01.raw	Raw
	141_0001_01A_R_SampleARep1FrB_06AUG21_CELL_HUM_ECL_0002_01AN_60MIN_MNM_RS_01.raw	Raw
	141_0001_01A_R_SampleARep1FrC_06AUG21_CELL_HUM_ECL_0002_01AN_60MIN_MNM_RS_01.raw	Raw
	141_0001_01A_R_SampleARep1FrD_06AUG21_CELL_HUM_ECL_0002_01AN_60MIN_MNM_RS_01.raw	Raw
	141_0001_01A_R_SampleARep1FrE_06AUG21_CELL_HUM_ECL_0002_01AN_60MIN_MNM_RS_01.raw	Raw

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Publications

KRAS-induced STN1 (OBFC1) promotes proper CTC1-STN1-TEN1 complex-independent DNA double-strand break repair and cell cycle checkpoint maintenance in pancreatic cancer.

Shen Changxian C Cui Tiantian T Yang Linlin L Gui Ling L Corrales-Guerrero Sergio S Nair Sindhu S Li Haiqing H Karasinska Joanna M JM Topham James T JT Renouf Daniel J DJ Schaeffer David F DF Fernandez Anthony A Ping Xiaoli X Shen Binghui B Stark Jeremy M JM Williams Terence M TM

Nucleic acids research 20250901 18

KRAS activating mutations occur in 90%-95% of pancreatic adenocarcinoma (PC) and contribute to tumor progression and resistance to therapy, including radiotherapy. A screen in isogenic cells revealed that KRAS activation positively modulates STN1 expression, a component of the CTC1-STN1-TEN1 (CST) complex. We find that STN1 is significantly upregulated in PC and its elevation is correlated with KRAS oncogenic mutations, while inhibition of KRAS signaling decreases STN1 expression. Interestingly, ...[more]

PMID: 41036624

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