Identification of proteins bound with RPA194 at rRNA loci in primary versus metastatic breast cancer cells

ABSTRACT: The nucleolus, the site of ribosome biogenesis, serves as a central hub for sensing and responding to cellular stress and plays a crucial role in this process; furthermore, emerging evidence highlights the potential role of ribosome biogenesis in driving metastasis. A combined approach of chromatin immunoprecipitation (ChIP) with mass spectrometry identified unique binding partners of RPA194 (the major subunit of RNA polI) in metastatic versus non-metastatic breast cancer cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Brandon Metge  

LAB HEAD: Dr. Lalita Samant

PROVIDER: PXD060651 | Pride | 2025-07-27

REPOSITORIES: Pride