HDX-MS analysis of the DNA-mKu interaction and dynamics

ABSTRACT: This project aims to decipher the DNA-protein interactions of the DNA end-binding protein mKu. In Mycobacterium tuberculosis and prokaryotes in general, Ku serves as the initiator of the non-homologous end-joining (NHEJ) DNA repair pathway. Using HDX-MS complemented with structural data, we investigate critical contacts at the DNA-protein interface and explore the dynamic behavior of the complex in solution.

INSTRUMENT(S):

ORGANISM(S): Mycobacterium Tuberculosis H37rv

DISEASE(S): Tuberculosis

SUBMITTER: Joydeep Baral  

LAB HEAD: Isabelle Rouiller

PROVIDER: PXD060776 | Pride | 2026-01-19

REPOSITORIES: Pride