Proteomic comparison of adipose tissue from obese insulin resistant subjects with obese insulin sensitive subjects

ABSTRACT: Tissues were collected during the Amsterdam (Netherlands) study of Carbohydrate Regulation of Lipid Metabolism ("SODA").  Subjects were divided between those with and without Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD); subjects were further divided by insulin resistance as assessed by hyperinsulinemic-euglycemic clamp.  Prior to bariatric surgery, subjects were given a glucose or fructose drink.  Subcutaneous and omental adipose tissues were collected during bariatric surgery.  Proteomic data was collected from both subcutaneous and omental adipose tissue; and from subjects given either carbohydrate drink (fructose or glucose).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): White Adipose Tissue, Abdominal Adipose Tissue, Subcutaneous Adipose Tissue

DISEASE(S): Obesity,Metabolic Dysfunction-associated Steatotic Liver Disease

SUBMITTER: Brandon Gassaway  

LAB HEAD: Steven Gygi

PROVIDER: PXD061142 | Pride | 2026-01-26

REPOSITORIES: pride