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Human skeletal muscle proteome responses to weight loss induced by bariatric surgery or low-calorie diet

ABSTRACT: Obesity has been linked to lower mitochondrial metabolism in skeletal muscle. Weight loss yields many metabolic advantages, yet the effect of bariatric surgery versus caloric restriction on skeletal muscle mitochondrial metabolism and proteome remains to be elucidated.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skeletal Muscle

DISEASE(S): Obesity

SUBMITTER: Eugene Dillon

LAB HEAD: Kirsi H. Pietiläinen

PROVIDER: PXD061410 | Pride | 2025-11-10

REPOSITORIES: Pride

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	2021_12_17_JamesWhite_MCRYO_01_0M.raw	Raw
	2021_12_17_JamesWhite_MCRYO_01_12M.raw	Raw
	2021_12_17_JamesWhite_MCRYO_01_5M.raw	Raw
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Publications

Effects of Whole-Body Cryotherapy Combined With Conventional Obesity Management Versus Obesity Management Alone: A Clinical Trial.

Karppinen Jari E JE Suojanen Laura L Heinonen Sini S Kaye Sanna S van der Kolk Birgitta W BW White James W JW Orava Janne J Lee Seung Hyuk T SHT Dillon Eugené E Muniandy Maheswary M Rissanen Aila A le Roux Carel W CW Docherty Neil N Pajukanta Päivi P Virtanen Kirsi A KA Pietiläinen Kirsi H KH

Obesity (Silver Spring, Md.) 20250903 11

<h4>Objective</h4>To investigate whether whole-body cryotherapy (WBC) enhances weight loss, brown adipose tissue (BAT) activation, and metabolic outcomes during obesity management.<h4>Methods</h4>Nineteen adults with obesity were assigned to a 12-month lifestyle-based obesity management intervention with 28 WBC sessions (-110°C, 3-4 min, ~2 × week) over the first 5 months (CRYO, n = 10) or the intervention without WBC (CON, n = 9). The primary outcome was weight loss (5 and 12 months). Secondary ...[more]

PMID: 40903800

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Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

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Mechanisms associated with systemic effects of cancer

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