Name: Proteomics on mdxmTR Mice
Keywords: Skeletal muscle

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Proteomics on mdxmTR Mice

ABSTRACT: Label free proteomics of skeletal muscle from mdxmTR mice.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle

DISEASE(S): Muscular Dystrophy

SUBMITTER: Brian McDonagh

LAB HEAD: Brian McDonagh

PROVIDER: PXD010507 | Pride | 2022-03-01

REPOSITORIES: Pride

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Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy.

Van Pelt Douglas W DW Kharaz Yalda A YA Sarver Dylan C DC Eckhardt Logan R LR Dzierzawski Justin T JT Disser Nathaniel P NP Piacentini Alex N AN Comerford Eithne E McDonagh Brian B Mendias Christopher L CL

Connective tissue research 20200715 1

<h4>Purpose/aim</h4>Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease characterized by extensive muscle weakness. Patients with DMD lack a functional dystrophin protein, which transmits force and organizes the cytoskeleton of skeletal muscle. Multiomic studies have been proposed as a way to obtain novel insight about disease processes from preclinical models, and we used this approach to study pathological changes in dystrophic muscles.<h4>Materials and methods</h4>We eval ...[more]

PMID: 32664808

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