Proteomics analysis of involvemnt of miRNA 465 in hybrid mouse sterility, 18 days

ABSTRACT: One of the reproductive isolation mechanisms that restricts gene exchange and make speciation irreversible is sterility of inter(sub)specific hybrids. In the Prdm9-driven sterility of Mus m. musculus x Mus m. domesticus hybrids a Prdm9-interacting hybrid sterility gene was mapped in the X-linked Hstx2 locus. Here we show that the Mir465 microRNA gene cluster is the predicted Hstx2 hybrid sterility factor involved in Prdm9 interaction.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Male Germ Cell

DISEASE(S): Disease Free

SUBMITTER: Lucie Pfeiferova  

LAB HEAD: Jiri Forejt

PROVIDER: PXD062724 | Pride | 2026-04-06

REPOSITORIES: Pride