Proteomic characterization of infant and adult ornithine aminotransferase-deficient mice

ABSTRACT: The deficiency of ornithine aminotransferase (OAT) cause gyrate atrophy, a progressive chorioretinal degeneration disease culminating in blindness. This project investigates age- and tissue-specific proteomic changes in the retina, retinal pigment epithelium (RPE), and liver of OAT-deficient mice to uncover the role of the enzyme in these tissues and the mechanisms underlying the eye damage.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retinal Pigment Epithelium Cell Line, Liver, Retina

SUBMITTER: Dennis Province  

LAB HEAD: Jianhai Du

PROVIDER: PXD063614 | Pride | 2026-07-06

REPOSITORIES: Pride