Mesothelin Promotes Acute Myeloid Leukemia Cell Proliferation, Adhesion, and Chemoresistance via Novel Binding Partner Lyn

ABSTRACT: MSLN has only been implicated to have one binding partner, MUC16/CA125. In an effort to identifying novel binding partners of MSLN, an IP-MS experiment was conducted using immunoprecipitations of MSLN in whole cell lysate of NOMO-1 and MSLN KO cells. We identified Src-family kinase member Lyn, and guanine nucleotide-binding protein G(i), alpha subunit proteins, GNAI1, GNAI2, and GNAI3 as a novel binding partners of MSLN in AML.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Acute Myeloid Leukemia Cell Line

SUBMITTER: Joshua Faust  

LAB HEAD: Sonali P. Barwe, PhD

PROVIDER: PXD067844 | Pride | 2026-04-27

REPOSITORIES: Pride