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Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways: A Proteomic Analysis

ABSTRACT: In this project expression proteomics of lung epithelia cells (Calu-3) was performed. Cells were either left untreated, or treated with 5 microM or 10 microM of Tetrandrine, in the absence or presence of SARS-CoV-2 infection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Covid-19

SUBMITTER: Joern Dengjel

LAB HEAD: Joern Dengjel

PROVIDER: PXD064448 | Pride | 2026-01-12

REPOSITORIES: Pride

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			Action	DRS
	20240622_MS_PP2428Sofia_T10W1.raw	Raw
	20240622_MS_PP2428Sofia_T10W2.raw	Raw
	20240622_MS_PP2428Sofia_T10W3.raw	Raw
	20240622_MS_PP2428Sofia_T10WO1.raw	Raw
	20240622_MS_PP2428Sofia_T10WO2.raw	Raw

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Publications

Tetrandrine-driven autophagy suppresses SARS-CoV-2 replication by modulating cholesterol and IGF signaling pathways.

Marchioro Lais de O LO De Stefanis Sofia S Araújo Beatriz G BG Mariotti Davide D Watanabe Ingrid K M IKM Stumpe Michael M Matusali Giulia G Maggi Fabrizio F Smaili Soraya S SS Dengjel Jörn J Pereira Gustavo J S GJS Antonioli Manuela M

Cell death discovery 20260106

SARS-CoV-2 exploits multiple host cellular processes, including autophagy, a critical intracellular degradation pathway, to facilitate viral replication and evade immune detection. Tetrandrine, a natural bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, has been reported to modulate autophagy and exhibits potential antiviral properties. In this study, we investigated the effects of Tetrandrine on SARS-CoV-2 infection in human lung epithelial cells (Calu-3), with a particular focu ...[more]

PMID: 41495014

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