Proteomics

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Comparative proteomic profiling of neonatal rat ventricular cardiomyocytes (NRVCMs) following TRIM24 overexpression

ABSTRACT: TRIM24 (Tripartite Motif-Containing 24) is a key transcriptional co-regulator involved in various cellular processes, including chromatin remodeling and gene expression. However, its role in cardiomyocytes remains largely unexplored. In this study, we investigated the global proteomic changes associated with TRIM24 overexpression in neonatal rat ventricular cardiomyocytes (NRVCMs) to better understand its function in cardiac biology. NRVCMs were transduced by an Adenovirus overexpressing TRIM24. Protein isolated from the NRVCMs transduced by an Adenovirus overexpressing LacZ was used as control.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Fetal Cardiomyocyte

SUBMITTER: Elke Hammer  

LAB HEAD: Elke Hammer

PROVIDER: PXD064832 | Pride | 2025-07-14

REPOSITORIES: Pride

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Dataset's files

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Action DRS
190326_RefSeq_rat_TRIM24.fasta Fasta
20191015_S1M1_DI_EH_DZHKi_Ctrl_OE_1_150min.raw.7z Raw
20191015_S1M1_DI_EH_DZHKi_Ctrl_OE_3_150min.raw.7z Raw
20191015_S1M1_DI_EH_DZHKi_Ctrl_OE_4_150min.raw.7z Raw
20191015_S1M1_DI_EH_DZHKi_TRIM24_OE_1_150min.raw.7z Raw
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Publications

TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes.

Neu Marco M   Deshpande Anushka A   Borlepawar Ankush A   Hammer Elke E   Alameldeen Ahmed A   Vöcking Phillipp P   Seeger Timon T   Hausmann Michael M   Frey Norbert N   Rangrez Ashraf Yusuf AY  

Cell communication and signaling : CCS 20250701 1

<h4>Background</h4>Cardiomyocyte proteostasis and calcium homeostasis are critical for maintaining cardiac function, with their dysregulation contributing to cardiac hypertrophy and heart failure. The Tripartite Motif Protein 24 (TRIM24), a well-characterized chromatin reader and transcriptional regulator in cancer, has recently emerged as a potential player in cardiac biology. However, its precise role in cardiomyocytes remains unclear. Using molecular, structural and functional approaches, thi  ...[more]

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