Proteomics

Dataset Information

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EDC exposure during SC-islet differentiation

ABSTRACT: We aimed to asses how EDC exposure in combination with a genetic predisposition for diabetes could impact pancreatic endocrine cell development. For this, we used a protocol to generate Stem-cell islets (SC-islets) from induced pluripotent stem cells (iPSCs) following a 7 satege protocol. For 2 weeks after pancreatic endocrine progenitor stage, cells were treated with a EDC mix of 1 nm of Bisphenol A, bisphenol S, and trans-nonachlor, or the vehicle DMSO. After those 2 weeks, the cells got a 1 week recovery period before collection. In the present study we used both iPSCs carrying the P291fsinC mutation in the HNF1A gene, and and isogenic non carrier control.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hipsc Cell

SUBMITTER: Thomas Aga Legøy  

LAB HEAD: Simona Chera

PROVIDER: PXD065436 | Pride | 2026-02-09

REPOSITORIES: Pride

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T1_SC-islet_Fraction_1.raw Raw
T1_SC-islet_Fraction_10.raw Raw
T1_SC-islet_Fraction_10_cal.mzIdentML Mzid
T1_SC-islet_Fraction_11.raw Raw
T1_SC-islet_Fraction_11_cal.mzIdentML Mzid
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Publications

Endocrine-disrupting chemical exposure during differentiation alters the proliferation-maturation balance in stem-cell islets.

Gudmestad June H JH   Unger Lucas L   Paulo Joao A JA   Ghila Luiza L   Legøy Thomas A TA  

Toxicological sciences : an official journal of the Society of Toxicology 20260101 1

Exposure to endocrine-disrupting chemicals (EDCs) is increasingly recognized as a risk factor for diabetes, primarily through disruption of pancreatic beta-cell function and insulin signaling. These effects can arise not only from adult exposure but also during development, as many EDCs can cross the placental barrier. However, models that accurately mimic human pancreatic islet development are limited. In this study, we reported the first toxicological application of stem cell islets (SC-islets  ...[more]

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