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Protoemics of nasal and bronchial mucus from primary human airway epithelial cells grown at air-liquid interface.

ABSTRACT: Differentiated primary human respiratory epithelial cells grown at air-liquid interface have become a widely used cell culture model of the human conducting airways. These cultures contain secretory cells such as goblet and club cells, which produce and secrete mucus. Here, we characterize the composition of mucus harvested from airway cultures of nasal and bronchial origin. We find that despite inter-donor variability, the protein content and composition is very similar between nasal and bronchial mucus. However, subtle differences in the abundance of individual components in nasal versus bronchial mucus can influence its antimicrobial properties.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Marie Pohl

LAB HEAD: Silke Stertz

PROVIDER: PXD066146 | Pride | 2025-08-13

REPOSITORIES: Pride

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			Action	DRS
	20231020_C33075_003_S577769_33075_multiplexed_fraction_2.raw	Raw
	20231020_C33075_004_S577770_33075_multiplexed_fraction_3.raw	Raw
	20231020_C33075_006_S577772_33075_multiplexed_fraction_5.raw	Raw
	20231020_C33075_007_S577773_33075_multiplexed_fraction_6.raw	Raw
	20231020_C33075_008_S577774_33075_multiplexed_fraction_7.raw	Raw

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