Dataset Information

The Human Lens Fiber Cytoskeletome Reveals Neuronal Signatures, and the presence of Chaperonins, Signaling, Proteasome and Redox Regulators

ABSTRACT: Morphogenesis, growth, shape, mechanics, and transparency of the ocular lens critically depend on cytoskeletal networks and cell adhesive interactions. However, the molecular composition of these cellular components of lens fibers remains to be defined in depth. This study is aimed at providing an unbiased and comprehensive characterization of cytoskeletal and cytoskeleton-associated proteins in human lens fibers.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Fibroblast

DISEASE(S): Disease Free

SUBMITTER: Nik Skiba

LAB HEAD: Ponugoti V. Rao

PROVIDER: PXD069327 | Pride | 2026-05-25

REPOSITORIES: Pride

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			Action	DRS
	03_28_25_Rupa_21_1.mzid	Mzid
	03_28_25_Rupa_21_1.mzid_03_28_25_Rupa_21_1.MGF	Mzid
	03_28_25_Rupa_21_1.raw	Raw
	03_28_25_Rupa_21_2.mzid	Mzid
	03_28_25_Rupa_21_2.mzid_03_28_25_Rupa_21_2.MGF	Mzid

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The Human Lens Fiber Cytoskeletome Reveals Neuronal Signatures and the Presence of Chaperonins, Proteasome, Signaling, and Redox Regulators.

Maddala Rupalatha R Lankford Levi K LK Skiba Nikolai P NP Rao Ponugoti V PV

Investigative ophthalmology & visual science 20260501 5

<h4>Purpose</h4>Morphogenesis, growth, shape, mechanics, and transparency of the ocular lens critically depend on cytoskeletal networks and cell adhesive interactions. However, the molecular composition of these cellular components of lens fibers remains to be defined in depth. This study is aimed at providing an unbiased and comprehensive characterization of cytoskeletal and cytoskeleton-associated proteins in human lens fibers.<h4>Methods</h4>Transparent lenses from young adult human donors (a ...[more]

PMID: 42149027

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