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Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells

ABSTRACT: Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. T cells fine-tune their sensitivity to and consumption of IL2 by regulating surface expression and composition of the IL2 receptor. Following antigen recognition, IL2 receptor signaling is polarized towards the immunological synapse. However, how IL2 function is integrated during earlier antigen-dependent T cell synapses is unknown. Here, we demonstrate a synergistic effect between the T cell receptor (TCR) and IL2 receptor signaling at the immunological synapse of CD8+ T cells. TCR and IL2 signaling overlapped in space and time, potentiating each other when simultaneously triggered. Immuno-STATs, a novel class of immunotherapeutics currently in clinical testing, fuse IL2 and peptide-major histocompatibility complex (pMHC) in a single molecule and generate immunological synapses synergistically enhancing both TCR and IL2R signaling to effectively expand antigen-specific CD8+ T cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Blood

SUBMITTER: iolanda Vendrell

LAB HEAD: Roman Fischer

PROVIDER: PXD070470 | Pride | 2026-07-06

REPOSITORIES: Pride

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			Action	DRS
	QE1900_MSQ2180_AshwinJ_10_CD8_activated.raw	Raw
	QE1900_MSQ2180_AshwinJ_11_CD8_activated.raw	Raw
	QE1900_MSQ2180_AshwinJ_12_CD8_activated.raw	Raw
	QE1900_MSQ2180_AshwinJ_1_CD4_resting_210814202528.raw	Raw
	QE1900_MSQ2180_AshwinJ_2_CD4_resting.raw	Raw

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