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ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia

ABSTRACT: We were interested in proteomic changes after depletion of the lipid metabolic gene Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) in human acute myleoid leukemia (AML) cell lines. We compared global protein alterations upon ACSL4 knockdown in one AML cell line harboring a lysine methyltransferase 2A (KMT2A) gene rearrangement (NOMO1) and two KMT2A WT AML cell lines (K562, MOLM16).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Acute Myeloid Leukemia Cell

SUBMITTER: Alexander Wurm

LAB HEAD: Alexander. Wurm

PROVIDER: PXD072756 | Pride | 2026-01-15

REPOSITORIES: Pride

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			Action	DRS
	2023-03-01_UP000005640_9606_one_prot_seq_per_gene.fasta	Fasta
	checksum.txt	Txt
	contaminants.fasta	Fasta
	oecf1-SS0813-01.raw	Raw
	oecf1-SS0813-02.raw	Raw

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ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia

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