Dataset Information

MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes

ABSTRACT: Doxorubicin-induced cardiomyopathy (DiCM) is a leading cause of heart failure and mortality in cancer patients, with doxorubicin-induced cardiomyocyte apoptosis constituting a fundamental pathological mechanism. Cardiac resident macrophages are primarily responsible for the effective clearance of apoptotic cardiomyocytes (efferocytosis), a process pivotal for suppressing inflammatory response and adverse cardiac remodeling. To identify genes implicated in DiCM, RNA sequencing was performed using heart tissues from saline- and DOX-treated wild-type (WT) mice. Ubiquitin mass spectrometry was used to identify the ubiquitin site of nuclear receptor subfamily 1 group H member 2 (NR1H2).

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: shuolin liu

LAB HEAD: Shuolin Liu

PROVIDER: PXD072759 | Pride | 2026-06-15

REPOSITORIES: Pride

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			Action	DRS
	SEARCH.zip	Other
	XA02959GP_NR1H2.raw	Raw
	checksum.txt	Txt

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Publications

MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes.

Liu Shuolin S Li Yiran E YE Zhu TingFang T Zhang LaiHai L Yang Cong C Bi YaGuang Y Bao Chenglong C Hu Ronggui R Ge Junbo J Zhang Yingmei Y

Nature communications 20260410 1

Doxorubicin-induced cardiomyopathy (DiCM) involves impaired clearance of apoptotic cardiomyocytes (efferocytosis) by cardiac macrophages. This study reveals a central role for the MARCH2-NR1H2 axis in this process. We find that MARCH2 expression is significantly reduced in cardiac macrophages from DiCM mice and human dilated cardiomyopathy patients. Genetic ablation of MARCH2, either globally (MARCH2<sup>-/-</sup>) or specifically in resident cardiac macrophages (MARCH2<sup>f/f</sup>; CX3CR1<sup ...[more]

PMID: 41963318

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