Dataset Information

Erk3 deletion drives oxidative adaptations in skeletal muscle

ABSTRACT: Skeletal muscle plays a central role in whole-body energy expenditure and metabolic homeostasis, and improving its mitochondrial function and oxidative fiber profile is considered an effective strategy to counteract diet-induced metabolic impairments, although the molecular regulators of these adaptations are not yet fully understood. Erk3 has been implicated in myotube differentiation and in skeletal muscle adaptations to aerobic exercise; however, its potential role in skeletal muscle during diet-induced metabolic dysfunction remains to be determined. Methods In this study, we used mice with striated muscle-specific Erk3 deletion alongside in vitro cultured myotubes, integrating metabolic phenotyping, indirect calorimetry, multi-omics profiling, and analyses of muscle morphology and fiber-type composition.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle Cell, Permanent Cell Line Cell

SUBMITTER: Frank Stein

LAB HEAD: Dioscuri Center for Metabolic Diseases

PROVIDER: PXD074086 | Pride | 2026-03-16

REPOSITORIES: Pride

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			Action	DRS
	2023-08-15-decoys-contam-merged_FASTA.fasta.fas	Fasta
	FragPipe_workflow.workflow	Other
	P2793_ion.tsv	Tabular
	P2793_peptide.tsv	Tabular
	P2793_protein.tsv	Tabular

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Erk3 deletion drives oxidative adaptations in skeletal muscle.

Loza-Valdes Angel A Acosta-Gallo Carlos C Kassouf Toufic T Belykh Andrei A Stelmach Małgorzata M Malińska Dominika D El Ghoz Katia K El-Merahbi Rabih R Dziaczkowski Filip F Kolczyńska-Matysiak Katarzyna K Sumara Grzegorz G

Molecular metabolism 20260224

<h4>Background</h4>Skeletal muscle plays a central role in whole-body energy expenditure and metabolic homeostasis, and improving its mitochondrial function and oxidative fiber profile is considered an effective strategy to counteract diet-induced metabolic impairments, although the molecular regulators of these adaptations are not yet fully understood. Erk3 has been implicated in myotube differentiation and in skeletal muscle adaptations to aerobic exercise; however, its potential role in skele ...[more]

PMID: 41740791

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