Dataset Information

Comparative Proteomic Analysis of Colorectal Cancer Stem Cells Reveals Potential Biomarkers and Altered Pathways

ABSTRACT: Label-free quantitative proteomic analysis of colorectal cancer stem cell (CSC)-enriched spheroids derived from SW620 and HCT-116 cell lines compared with their corresponding parental adherent cells using LC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Malignant Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Ola Hussein

LAB HEAD: Hesham Mohamed Korashy

PROVIDER: PXD075150 | Pride | 2026-06-08

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	HCT116_CSCs_InSolDig_001.d.zip	Other
	HCT116_CSCs_InSolDig_002.d.zip	Other
	HCT116_CSCs_InSolDig_003.d.zip	Other
	HCT116_Cancer_Cells_InSolDig_001.d.zip	Other
	HCT116_Cancer_Cells_InSolDig_002.d.zip	Other

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Publications

Comparative proteomic analysis of colorectal cancer stem cells reveals potential biomarkers and altered pathways.

Hussein Ola J OJ Therachiyil Lubna L Younis Shahd M SM Itani Shaymaa S Abunada Hanan H HH Tout Issam I Maccalli Cristina C Korashy Hesham M HM

Frontiers in molecular biosciences 20260420

<h4>Background</h4>Colorectal cancer (CRC) initiating/stem cells (CICs/CSCs) represent a rare tumor subpopulation with self-renewal capacity that drives tumor progression, recurrence, therapeutic resistance, and immune evasion. Despite extensive efforts to define CSCs using surface and functional markers, no universally accepted marker exists for CSC isolation and enrichment. Moreover, the molecular mechanisms underlying CSC-associated phenotypes remain incompletely characterized, highlighting t ...[more]

PMID: 42088942

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