H3pT11 regulates histone homeostasis and replication-coupled nucleosome assembly
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ABSTRACT: newly synthesized H3 is phosphorylated at T11 by the CPC complex, licensing Asf1 binding and nuclear import; upon nuclear entry, H3pT11 facilitates Rtt109-catalyzed H3K56 acetylation, which antagonizes Hat1 and promotes nucleosome assembly by CAF-1 and Rtt106 16; subsequently, Rtt101-mediated H3K122 ubiquitination destabilizes the Asf1-H3/H4 interaction, enabling dimer transfer from Asf1 to CAF-1
INSTRUMENT(S):
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER:
Yu Qi
LAB HEAD: Yu qi
PROVIDER: PXD077347 | Pride | 2026-08-05
REPOSITORIES: Pride
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