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Mus musculus

ABSTRACT: Comparison of the binding patterns of the Rest complex between embryonic stem cells and epiblast stem cells. (mEpiSC)

PROVIDER: PRJDB2513 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR014790.fastq.gz	Fastqsanger.gz
	DRR014791.fastq.gz	Fastqsanger.gz
	DRR014792.fastq.gz	Fastqsanger.gz
	DRR014793.fastq.gz	Fastqsanger.gz
	DRR014794.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:Comparison of the binding patterns of the Rest complex between embryonic stem cells and epiblast stem cells. (mE14)

| PRJDB1964 | ENA

Polycomb Repressor Complex 2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.

Project description:These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results showed that a majority of REST-bound genomic regions were not associated with H3K27me3 enrichment and loss of H3K27me3 enrichment was not a general observation in REST -/- ESCs. These results support the conclusion that REST and PRC2 function independently in ESCs and similarly contribute to maintaing a transcriptionally poised state through antagonism of H3K4me3. Examination of REST-bound regions in undifferentiated mouse embryonic stem cells (ESC), and a comparison of H3K27me3 distribution between WT and REST-/- ESCs.

2014-09-30 | E-GEOD-48320 | biostudies-arrayexpress

Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation [EXP5_ChIPSeq]

Project description:In this experiment the binding of SOX2, B-catenin, and LEF1 was assayed using ChIP-seq following differentiation of WT, T/Bra mutant, and Cdx1,2,4 triple mutant embryonic stem cells to caudal ebiblast progenitors. SOX2 binding in epiblast cells was assayed for comparison.

2021-12-31 | GSE180745 | GEO

Metabolomics Workbench ST000003 - GNPS - Metabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells

Project description:mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells were compared via metabolomic analysis

2018-08-02 | MSV000082680 | GNPS

Transcription profiling of mouse embryonic stem cells, inner cell mass, epiblast and pluripotent cells derived from mouse epiblast under defined culture conditions

Project description:Transcriptional comparison of mouse embryonic stem cells, inner cell mass, epiblast and pluripotent cells derived from mouse epiblast under defined culture conditions.

2007-06-22 | E-MEXP-955 | biostudies-arrayexpress

Mus musculus

Project description:RNA sequencing of Epiblast stem cells, nodal inhibited epiblast stem cells and embryonic samples

| PRJNA358283 | ENA

RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (RNA)

Project description:We performed an integrated analysis of RNA and proteins at the transition between naÃ¯ve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC). This suggests that, prior to differentiation, the propensity of ES cells to change their epigenetic status is hampered by RNA interference. The expression of these chromatin regulators was reinstated following acute inactivation of RISC, and it correlated with loss of stemness markers and activation of early cell differentiation markers in treated ES cells. Comparison between EpiSC derived directly from mouse embryonic stem cells and from Epiblast-Like Aggregates

2016-03-29 | E-GEOD-79650 | biostudies-arrayexpress

Project description:Expression profiles of epiblast stem cells and embryonic stem cells

| PRJNA119211 | ENA

TAF4 immunoprecipitation from mouse embryonic stem cells

Project description:TAF4 directed immunoprecipitation of the the Pre-initiation complex from mouse embryonic stem cells with or without depletion of TATA-box binding protein (TBP).

2022-05-27 | MSV000089562 | MassIVE

REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

Project description:Genome-wide analysis of REST and Polycomb binding in Rest-/- and Eed-/- mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently of CpG islands and the H3K27Me3 mark., and that PRC2 was frequently increased around Rest binding sites located in CpG-rich regions in the Rest2/2 mES cells. Published here: PLoS Genet 8(3): e1002494. doi:10.1371/journal.pgen.1002494

2013-06-20 | GSE48122 | GEO

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