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Bacillus anthracis

ABSTRACT: Whole genome sequencing of Bacillus anthracis isolated in Vietnam

PROVIDER: PRJDB7324 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	DRR166482_1.fastq.gz	Fastqsanger.gz
	DRR166482_2.fastq.gz	Fastqsanger.gz
	DRR166483_1.fastq.gz	Fastqsanger.gz
	DRR166483_2.fastq.gz	Fastqsanger.gz

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Expression analysis of Bacillus anthracis Sterne wild-type and deltaClpX mutant strains

Project description:Investigation of whole genome expression level changes in Bacillus anthracis Sterne deltaClpX mutant compared to the wild-type strain after growth in nutrient rich media. The deltaClpX mutant used in this study is described in McGillivray et al. 2009. ClpX Protease Contributes to Antimicrobial Peptide Resistance and Virulence Phenotypes of Bacillus anthracis. Journal of Innate Immunity 1(5): 494-506.

2018-02-14 | GSE94398 | GEO

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Direct regulons of the master virulence regulator AtxA of Bacillus anthracis

Project description:AtxA, the master virulence regulator of Bacillus anthracis, regulates the expression of three toxins that are required for the pathogenicity of Bacillus anthracis. Recent transcriptome analyses also showed that AtxA affects a large number of genes on both chromosome and plasmid, suggesting its role as a global regulator. Its mechanism of gene regulation nor binding target in vivo was, however, not well understood. In this work, we conducted ChIP-seq for cataloging binding sites of AtxA in vivo and Cappable-seq for catalogging the transcription start sites on the B. anthracis genome. For detected regulons, single knockout strains were constructed and RNA-seq was conducted for each strain.

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Comparative Genomics of Bacillus cereus and Bacillus anthracis

Project description:The aim of the study was to carry out a CGH study utilizing a set of 39 diverse Bacillus isolates. Thirty four B. cereus and five B. anthracis strains and isolates were chosen so as to represent different lineages based on previous characterizations, including MLEE and MLST (Helgason, Okstad et al. 2000; Helgason, Tourasse et al. 2004). They represent the spectrum of B. cereus phenotypic diversity by including soil, dairy and periodontal isolates in addition to virulent B. anthracis strains.

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Bacillus anthracis

Project description:Whole genome sequencing of Bacillus anthracis

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Bacillus anthracis Stern 34F2 sporulation

Project description:Timecourse from log phase growth to sporulation in Bacillus anthracis Stern 34F2

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Bacillus anthracis gene expression upon plantazolicin and Me2-Arg-Az5

Project description:Subinhibitory concentrations of compound used to assess their influence on the gene expression profile of Bacillus anthracis.

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Transcriptome of Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers

Project description:We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours

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Laboratory adaptation of Bacillus anthracis

Project description:The spore forming pathogen Bacillus anthracis is the etiologic agent of anthrax in humans and animals. It cycles through infected hosts as vegetative cells and is eventually introduced into the environment where it generates an endospore resistant to many harsh conditions. The endospores are subsequently ingested by the next host to begin the next cycle. Outbreaks of anthrax occur regularly worldwide in wildlife and livestock, and the potential for human infection exists whenever humans encounter infected animals. It is also possible to encounter intentional releases of anthrax spores, as was the case in October 2001. Consequently, it is important to be able to rapidly establish the provenance of infectious strains of B. anthracis. Here, we compare protein expression in seven low-passage wild isolates and four laboratory strains of B. anthracis grown under identical conditions using LC-MS/MS proteomic analysis. Of the 1,023 total identified proteins, 96 had significant abundance differences between wild and laboratory strains. Of those, 28 proteins directly related to sporulation were upregulated in wild isolates, with expression driven by Spo0A, CodY, and AbrB/ScoC. In addition, we observed evidence of changes in cell division and fatty acid biosynthesis between the two classes of strains, despite being grown under identical experimental conditions. These results suggest wild B. anthracis cells are more highly tuned to sporulate than their laboratory cousins, and this difference should be exploited as a method to differentiate between laboratory adapted cultures and low passage wild strains isolated during an anthrax outbreak. This knowledge should distinguish between intentional releases and exposure to strains in nature providing a basis for the type of response by public health officials and investigators.

2018-12-04 | PXD010120 | Pride

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