Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human gut metagenome

ABSTRACT: Resistant maltodextrin intake reduces virulent metabolites in the gut environment: randomised control study

PROVIDER: PRJDB9705 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR223367_1.fastq.gz	Fastqsanger.gz
	DRR223367_2.fastq.gz	Fastqsanger.gz
	DRR223368_1.fastq.gz	Fastqsanger.gz
	DRR223368_2.fastq.gz	Fastqsanger.gz
	DRR223369_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 116

Similar Datasets

Transcriptomic profiling of insecticide resistant field Anopheles funestus from Tanzania compared to a fully susceptible laboratory strain

Project description:Comparative gene expression profiling of Anopheles funestus insecticide resistant field strain from an area of a major insecticide treated bednet randomised control trial

2021-06-03 | E-MTAB-10579 | biostudies-arrayexpress

Transcriptomic profiling of insecticide resistant field Anopheles gambiae from Tanzania compared to fully susceptible laboratory strains

Project description:Comparative gene expression profiling of Anopheles gambiae insecticide resistant field strain from an area of a major insecticide treated bednet randomised control trial

2021-06-03 | E-MTAB-10580 | biostudies-arrayexpress

gut metagenome

Project description:Inulin intake suppresses SARS-CoV-2 infection by improving the intestinal environment

| PRJDB16057 | ENA

Intestinal lipid metabolism regulates absorption and surface of gut epithelium

Project description:Intestinal surface changes in size and function in response to environmental conditions, but what propels these alterations and what are the metabolic consequences is not clear. Here we show that in mice gut surface enlarges by increasing food amount rather than caloric intake, contributing to an increased absorptive function, and that it can be reversed by reducing daily food amount. Genetic- and environment-induced gut enlargement due to overeating is principally supported by upregulation of the intestinal lipid metabolism and transport. Intestinal knock-out, and pharmacological inhibition of PPARα supress intestinal crypt formation and shorten villi in the small intestine of mice and in human intestinal biopsies, respectively, and diminish post-prandial triglyceride transport and nutrient uptake. PPARα inhibition limits lipid absorption and restricts lipid droplet growth and PLIN2 levels, critical for the droplet formation. This improves lipid metabolism, reduces body adiposity and liver steatosis, suggesting an alternative target for treating obesity.

2021-09-02 | GSE152056 | GEO

Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring (Gene expression data)

Project description:Scope: The âPredictive Adaptive Responseâ hypothesis suggests the in utero environment when mismatched with the post-natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mechanisms. Methods and Results: In a 2x2 factorial design, female C57Bl/6 mice were randomised to low or normal folate diets (0.4mg/ or 2mg folic acid/kg diet) prior to and during pregnancy and lactation with. At weaning, offspring were randomised to high or low fat diets at weaning. Genome-wide gene expression and promoter DNA methylation were measured using microarrays in adult male livers. Maternal folate depletion and high fat intake post-weaning influenced gene expression (1959 and 1612 genes respectively) and promoter DNA methylation (208 and 344 loci respectively) but changes in expression and methylation were poorly matched for both dietary interventions. Expression of 667 genes was altered in response to both maternal folate depletion and post-weaning high fat feeding. In addition, there was evidence that the combined dietary insult (i.e. maternal folate depletion followed by high fat post-weaning) exerted the largest expression change for most of these genes. Conclusion: Our observations align with, and provide evidence in support of a potential underlying mechanism for, the âPredictive Adaptive Responseâ hypothesis. Elucidation of these mechanisms may identify targets for interventions to mitigate effects of adverse nutrition exposures during early development on disease risk in later life.

2017-05-22 | E-MTAB-4987 | biostudies-arrayexpress

Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring (DNA methylation data)

Project description:Abstract Scope: The âPredictive Adaptive Responseâ hypothesis suggests the in utero environment when mismatched with the post-natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mechanisms. Methods and Results: In a 2x2 factorial design, female C57Bl/6 mice were randomised to low or normal folate diets (0.4mg/2mg folic acid/kg diet) prior to and during pregnancy and lactation with, offspring randomised to high or low fat diets at weaning. Genome-wide gene expression and promoter DNA methylation were measured using microarrays in adult male livers. Maternal folate depletion and high fat intake post-weaning influenced gene expression (1959 and 1612 genes respectively) and promoter DNA methylation (208 and 344 loci respectively) but changes in expression and methylation were poorly matched for both dietary interventions. Expression of 667 genes was altered in response to both maternal folate depletion and post-weaning high fat feeding. In addition, there was evidence that the combined dietary insult (i.e. maternal folate depletion followed by high fat post-weaning) exerted the largest expression change for most of these genes. Conclusion: Our observations align with, and provide evidence in support of a potential underlying mechanism for, the âPredictive Adaptive Responseâ hypothesis. Elucidation of these mechanisms may identify targets for interventions to mitigate effects of adverse nutrition exposures during early development on disease risk in later life.

2017-05-22 | E-MTAB-4990 | biostudies-arrayexpress

Modulation of the post meal PBMC transcriptomic response of shift workers after four weeks of a dietary intervention implementing a dedicated overnight fast

Project description:In a cross-over randomised controlled trial,19-night shift workers with abdominal obesity, completed two diet conditions separated by a two week wash out period; a) the control period = four weeks of habitual eating overnight and b) the intervention period = four weeks of avoiding food intake between 1 AM – 6 AM. At the end of each intervention period participants were given a high fat/high carbohydrate challenge meal in the morning and peripheral blood mononuclear cells were isolated from whole bood sampled at fasting, 2 and 4 hours after eating the meal.

2024-02-16 | GSE225493 | GEO

Influence of the WCRF-AICR diet and prebiotics on gut microbiome and inflammation in patients at high risk of colorectal cancer

Project description:Intervention group:Prebiotics and WCRF-AICR diet intervention;Control group:Maltodextrin placebo Primary outcome(s): Intestinal flora;Stool inflammation marker content Study Design: Parallel

| 2706512 | ecrin-mdr-crc

Proteomics of Resistance to Halo Blight in Common Bean

Project description:Phaseolus vulgaris was inoculated with water, and Pseudomonas syringae pv phasiolicola R5 (avirulent) and R8 (virulent) and sampled 24 h later. Tags 126, 127N, and 128C were assigned to water-treated control replicates; tags 129C, 130N, and 131 were assigned to R8-inoculated (susceptible) replicates; and tags 127C, 128N and 130C were assigned to R5-inoculated (resistant) replicates.

2019-12-19 | MSV000084725 | MassIVE

Metaproteomics and metabonomics reveal the metabolic dysfunction of gut microbiota in the Tibetan Minipigs with atherosclerosis

Project description:Atherosclerosis is fundamental in the development of cardiovascular disease. The unhealthy dietary habits, high fat and cholesterol intake could change the composition of gut microbes and metabolites which play a critical role in the development of atherosclerosis. To characterize the functionality of intestinal microbiome in the AS, we performed an analysis of microbiota proteins by a metaproteomics technique in 6 control samples and 6 feces samples. Using data dependent acquisition (DDA), a total of 8467 peptides with taxonomy annotation were identified and which were correspond to 3851 protein groups.

2024-06-13 | PXD053097 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data