Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CC5 Staphylococcus aureus

ABSTRACT: Genomic and epidemiological evidence of a dominant Panton-Valentine leucocidin-positive Methicillin Resistant Staphylococcus aureus lineage in Sri Lanka with spread to the United Kingdom and Australia

PROVIDER: PRJEB27049 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR2639480_1.fastq.gz	Fastqsanger.gz
	ERR2639480_2.fastq.gz	Fastqsanger.gz
	ERR2639490_1.fastq.gz	Fastqsanger.gz
	ERR2639490_2.fastq.gz	Fastqsanger.gz
	ERR2639500_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 274

Similar Datasets

Panton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA

2008-09-12 | GSE8677 | GEO

Panton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA

Project description:Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect bacterial clearance from lungs, spleen and kidneys in a highly discriminatory rabbit bacteremia model. These findings negate a large body of epidemiological research that implicated PVL in CA-MRSA virulence. Keywords: mutant vs wild type in 2 different growth phases grown in 2 different medias Wild type USA 300 (strain SF8300), wild type USA 400 (strain MW2) were compared against their respective PVL isogenic knock out strains. Strains were compared at both mid-exponential and stationary phase and grown in both TSB and CCY to determine if PVL plays a role in gene regulation under these conditions.

2010-06-19 | E-GEOD-8677 | biostudies-arrayexpress

WGS of Panton-Valentine leucocidin methicillin-resistant Staphylococcus aureus

Project description:WGS of Panton-Valentine leucocidin methicillin-resistant Staphylococcus aureus

| PRJEB65285 | ENA

Whole genome expression in peripheral whole blood of chronic kidney disease patients having uncertain etiology (CKDu) compared to healthy controls

Project description:Chronic kidney disease of uncertain etiology (CKDu) is an increasing problem in Sri Lanka especially among the farming community. The etiologies although uncertain, have been associated with occupational and environmental factors. The expression pattern of genes in blood of these CKDu patients in an endemic region of Sri Lanka was analyzed compared to healthy individuals from a non-endemic region to see any expression changes that could be associated to environmental factors. Pattern of expression changes could lead to either strengthen or weaken current hypotheses for the causes.

2018-12-30 | GSE62792 | GEO

Comparison of S. aureus PVL-positive and PVL-negative isogenic strains in exponential and stationary phase of growth

Project description:The Staphylococcus aureus Panton Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model. Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell-wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa). Keywords: comparative transcription profile in the presence or absence of PVL toxin

2007-02-13 | GSE6985 | GEO

Project description:Panton-Valentine Leukocidin-positive Methicillin-resistant Staphylococcus aureus in Saxony, Germany, 2019

| PRJNA957965 | ENA

OSCC CGH SriLanka vs India

Project description:In Asia, oral cancer (OC) and oral submucous fibrosis (OSF) constitute major health problems linked to use of betel quid. This work performed CGH genome-wide analysis of OC (12 from India, 12 from Sri Lanka) and OSF (6 from India) cases with normal controls.

2011-11-30 | E-MTAB-819 | biostudies-arrayexpress

Project description:Sri Lanka Metagenomes

| PRJNA556989 | ENA

human metagenome

Project description:OSCC Bacteriome -Sri Lanka

| PRJNA415963 | ENA

A point mutation in the agr locus caused previously reported phenotypes in Staphylococcus aureus pneumonia

Project description:The role of Panton‐Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeira‐Rey et al. (Science 315:1130‐3, 2007). In agreement with previous studies that failed to detect similar effects of PVL using community‐associated methicillin‐resistant S. aureus strains, we found no significant impact of PVL on gene expression or pathogenesis after we repaired the mutation. These findings further contribute to the idea that PVL does not have a major impact on S. aureus pathogenesis and resolve debate about its role in murine infection models. Moreover, our results demonstrate that a single nucleotide polymorphism in an intergenic region can dramatically impact bacterial physiology and virulence. Finally, our work emphasizes the need to frequently evaluate the integrity of the S. aureus agr locus.

2009-12-31 | GSE14394 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data