Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Miage Galcier

ABSTRACT: Fungal ecology of Miage Glacier (Italy)

PROVIDER: PRJEB30926 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3090760_1.fastq.gz	Fastqsanger.gz
	ERR3090760_2.fastq.gz	Fastqsanger.gz
	ERR3090770_1.fastq.gz	Fastqsanger.gz
	ERR3090770_2.fastq.gz	Fastqsanger.gz
	ERR3090751_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 50

Similar Datasets

Project description:Microbial Ecology of equatorial Lewis Glacier, Kenya

| PRJNA589711 | ENA

Project description:Fungal diversity in Boulder Clay glacier (Antarctica)

| PRJEB33266 | ENA

Contribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice

Project description:The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fungi, or both to differentiate the causal role of fungi on microbiome assembly, immune development, susceptibility to colitis, and airway inflammation. Fungal colonization promotes major shifts in bacterial microbiome ecology, and has an independent effect on innate and adaptive immune development in young mice. While exclusive fungal colonization is insufficient to elicit overt dextran sulfate sodium-induced colitis, bacterial and fungal co-colonization increase colonic inflammation. Ovalbumin-induced airway inflammation reveals that bacterial, but not fungal colonization is necessary to decrease airway inflammation, yet fungi selectively promotes macrophage infiltration in the airway. Together, our findings demonstrate a causal role for fungi in microbial ecology and host immune functionality, and therefore prompt the inclusion of fungi in therapeutic approaches aimed at modulating early life microbiomes.

2022-01-14 | MTBLS1679 | MetaboLights

Amoeba Predation of Cryptococcus: A Quantitative and Population Genomic Evaluation of the Accidental Pathogen Hypothesis

Project description:The “Amoeboid Predator-Fungal Animal Virulence Hypothesis” posits that interactions with environmental phagocytes shape the evolution of virulence traits in fungal pathogens. In this hypothesis, selection to avoid predation by amoeba inadvertently selects for traits that contribute to fungal escape from phagocytic immune cells. Here, we investigate this hypothesis in the human fungalpathogens Cryptococcus neoformans and Cryptococcus deneoformans. Applying quantitative trait locus (QTL) mapping and comparative genomics, we discovered a cross-species QTL region that is responsible for variation in resistance to amoeba predation. In C. neoformans, this same QTL was found to have pleiotropic effects on melanization, an established virulence factor. Through fine mapping and population genomic comparisons, we identified the gene encoding the transcription factor BZP4 that underlies this pleiotropic QTL and we show that decreased expression of this gene reduces melanization and increases susceptibility to amoeba predation. Despite the joint effects of BZP4 on amoeba resistance and melanin production, we find no relationship between BZP4 genotype and escape from macrophages or virulence in murine models of disease. Our findings provide new perspectives on how microbial ecology shapes the genetic architecture of fungal virulence, and suggests the need for more nuanced models for the evolution of pathogenesis that account for the complexities of both microbe-microbe and microbe-host interactions.

2023-07-25 | GSE238170 | GEO

Clinical and prognostic relevance of squalene epoxidase in breast cancer

Project description:All cell lines were purchased from ATCC (LGC Standards S.r.l., Milan, Italy), except T-47D and MDA-MB-468 that were obtained from the National Cancer Institute Developmental Therapeutics Program (Frederick, MD).

2015-07-28 | GSE71395 | GEO

Iceman stomach content - The 5300-year-old Helicobacter pylori genome of the Iceman

Project description:Shotgun LC-MS/MS analysis of three stomach content samples of the Iceman, a 5300-year-old European glacier mummy.

2018-07-20 | PXD009565 | Pride

Project description:Fungal fairy rings in a grassland (Aremogna, Italy)

| PRJNA1281375 | ENA

EPIC-Italy at HuGeF

Project description:This Series contains data from 845 participants (188 men and 657 women) in the EPIC-Italy cohort that was produced at the Human Genetics Foundation (HuGeF) in Turin, Italy. At the last follow-up (2010), 424 participants remained cancer-free, 235 had developed primary breast cancer, 166 had developed primary colorectal cancer, and 20 had developed other primary cancers. Anthropometric measurements, and dietary and lifestyle information obtained by questionnaire are also available.

2013-09-20 | GSE51032 | GEO

Project description:Ecology of the Lactobacillus genus across raw milk-based cheeses produced in Italy

| PRJNA596087 | ENA

Methylome Analysis and Epigenetic Changes Associated with Menarcheal Age

Project description:Epigenome-wide association study of age at menarche in a group of 329 women from the EPIC-Italy cohort.

2013-09-21 | GSE51057 | GEO