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RNA Sequencing of LT-HSCs and ST-HSCs from healthy adult human Bone Marrow

ABSTRACT: RNA Sequencing of LT-HSCs and ST-HSCs from healthy adult human Bone Marrow

PROVIDER: PRJEB41856 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4972860_1.fastq.gz	Fastqsanger.gz
	ERR4972860_2.fastq.gz	Fastqsanger.gz
	ERR4972861_1.fastq.gz	Fastqsanger.gz
	ERR4972861_2.fastq.gz	Fastqsanger.gz
	ERR4972862_1.fastq.gz	Fastqsanger.gz

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RNA Sequencing of LT-HSCs and ST-HSCs from healthy adult human Bone Marrow

Project description:The transcriptome of LT-HSC (CD34+CD38-CD45RA+CD90+CD49f+) and ST-HSC (CD34+CD38-CD45RA+CD90-CD49f-) from healthy adult human Bone Marrow Cells were assessed by RNA-seq.

2022-04-06 | E-MTAB-9892 | biostudies-arrayexpress

Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

Project description:We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily performed comprehensive gene expression profiling of CreER-transduced LT-HSCs and ST-HSCs using cDNA microarray analysis. For initial screening of candidate genes invloved in the leukemic transformation, total RNA was extracted from colony-forming cells derived from LT-HSCs and ST-HSCs transduced with CreER or mock. Four samples were analyzed, and CreER-transduced LT/ST-HSC-derived cells were compared with mock-transduced LT/ST-HSC-derived cells, while CreER/mock-transduced LT-HSC-derived cells were compared with CreER/mock-transduced ST-HSC-derived cells.

2013-07-17 | E-GEOD-48539 | biostudies-arrayexpress

Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

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Transcriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.

Project description:Transcriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.

| PRJNA941818 | ENA

Transcriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.

Project description:Here, we used bulk-RNAseq of bulk-HSCs (Lineage-c-Kit+Sca-1+CD150+CD34-/loFlk2- ), LT-HSCs (Hoxb5+Lineage-c-Kit+Sca-1+CD150+CD34-/loFlk2- ), and ST-HSCs (Hoxb5-Lineage-c-Kit+Sca-1+CD150+CD34-/loFlk2- ) from young (2-3 months) or aged (23-25 months) mice to compare age-associated transcriptomic changes.

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Single Cell RNA Sequencing of human bone marrow LT-HSCs.

Project description:10x single cell sequencing of LT-HSCs (CD34+CD38-CD90+CD45RA-CD49f+) from human bone marrow.

2022-04-06 | E-MTAB-9922 | biostudies-arrayexpress

RNA sequencing of eGFPlo and eGFPhi LT-HSCs in the bone marrow from Trim47+/eGFP mice

Project description:eGFPlo and eGFPhi LT-HSCs in the bone marrow from Trim47+/eGFP mice were isolated to explore the differentially expressed genes by RNA-seq.

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Single Cell RNA Sequencing of human bone marrow LT-HSCs.

Project description:Single Cell RNA Sequencing of human bone marrow LT-HSCs.

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Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment

Project description:The vulnerability of bone marrow hematopoiesis to perturbations of cholesterol metabolism is well documented, while the underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct cholesterol metabolic signature of hematopoietic stem cells (HSCs) within the hematopoietic compartment.To identify the phenotype switching and function variation in BM LT-HSCs with HCD treatment, we performed RNA-seq of LT-HSCs from the bone marrow of mice with or without3-month HCD treatment.

2023-03-29 | GSE214035 | GEO

Expression data from LT-HSCs from bone marrow non-irradiated, 8Gy CDR and 8Gy FLASH total body irradiated mice

Project description:Total body irradiation (TBI) of mice using two dose rates, conventional dose rate (CDR) versus flash dose rate (FLASH), induced transient decrease of number of LT-HScs in bone marrow and a total recovery of these cells 15 days after TBI We used microarrays to detail the global programme of gene expression underlying the recovery of LT-HSCs and identified distinct classes of up or down- regulated genes according the modality of irradiation

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