Project description:Genome wide DNA methylation profiling of muscle tissue genomic DNA. The Illumina Infinium MethylationEPIC array was used to obtain DNA methylation profiles across approximately 850,000 CpGs. Samples were male, taken from both the Hertfordshire Sarcopenia Study (HSS, n=34) and the Hertfordshire Sarcoepnia Study exension (HSSe, n=44), to determine DNA methylation associations with measures of muscle mass and function. We further aimed to test whether differences in the muscle methylome are associated with sarcopenia in older individuals. We found significant associations between DNA methylation in the muscle tissue and sarcopenia, as well as individual measures of muscle mass and function, enriched around EZH2 binding sites.

2021-12-15 | GSE154980 | GEO

Microbiota, Appetite, and Malnutrition in Dutch Community-dwelling older adults

Project description:This concerns a cross-sectional cohort study of 356 Dutch community-dwelling older adults to study the association of the oral microbiota with poor taste, poor smell, poor appetite and undernutrition. Data-collection consisted of body measurements (incl. body weight, height, and body impedance analysis), extensive appetite and food frequency questionnaires, taste and smell tests, and a tongue swab. The oral microbiota composition was assessed with 16S rRNA sequencing.

| EGAS00001005319 | EGA

Exploratory Multi-Omics Analysis of Gut Microbiota and Fecal Metabolites in Relation to Serum S-Equol Levels in Older Adults with Osteoporosis from a Tropical Community: A Pilot Study

Project description:<p>This study aimed to investigate fecal metabolomic profiles associated with osteoporosis and serum S-equol levels in community-dwelling older adults from a tropical region of China. Fecal samples were collected from participants classified as osteoporosis or non-osteoporosis based on bone mineral density measurements. Untargeted metabolomics analysis was performed to characterize metabolic differences between groups and to explore associations between fecal metabolites and circulating S-equol levels. The generated metabolomic data were further integrated with gut microbiota profiling and clinical parameters to provide an exploratory assessment of microbial–metabolic features related to bone health.</p>

2026-02-10 | MTBLS13855 | MetaboLights

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming

Project description:Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. To address this gap, we employed an established neonatal overfeeding model by reducing litter size, assigning litters to either 4 pups per dam (Overfed group) or 8 pups per dam (Normal-fed control group). To directly examine whether microbiota alterations mediate neonatal overnutrition-induced acceleration of sarcopenia, we performed fecal microbiota transplantation (FMT) experiments. We transplanted microbiota from either aged normal-fed or overfed donor mice into adult recipients (rNormal and rOver groups) maintained on a high-fat diet (HFD) for 20 weeks to accelerate the onset of metabolic and muscular dysfunction. These findings reveal a developmental origin of age-related sarcopenia and define a gut-muscle axis linking childhood overnutrition to muscle aging.

2026-08-27 | GSE305875 | GEO

Physical fitness in community dwelling older adults is linked to dietary intake, gut microbiota and metabolomic signatures

Project description:Physical fitness in community dwelling older adults is linked to dietary intake, gut microbiota and metabolomic signatures

| PRJEB33008 | ENA

Study of sarcopenia in human muscle biopsies of elderly individuals, Jamaica Sarcopenia Study

Project description:Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from muscle impaired versus healthy subjects. Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls.

2019-11-14 | GSE111010 | GEO

Study of sarcopenia in human muscle biopsies of elderly individuals, Hertfordshire Sarcopenia Study

Project description:Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from sarcopenic versus healthy subjects. Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls.

2019-11-14 | GSE111006 | GEO

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