Microbiome dysbiosis in HIV infected patients
Ontology highlight
ABSTRACT:
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ERR408141.fastq.gz | Fastqsanger.gz | |||
| ERR408142.fastq.gz | Fastqsanger.gz | |||
| ERR408143.fastq.gz | Fastqsanger.gz | |||
| ERR408144.fastq.gz | Fastqsanger.gz | |||
| ERR408145.fastq.gz | Fastqsanger.gz |
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Project description:Current therapy has turned HIV infection into a chronic condition. Clinically, some patients suffer prematurely from ailments associated with advanced age; however, the relationship between HIV and aging is unclear. Here we have collected a large cohort of HAART treated HIV+ subjects with both recent and chronic infection and recapitulated the shared phenotype of HIV and age. To further understand this signal, we applied validated models of DNA methylation-based biological age to establish a clear link between HIV infection and molecular age advancement. We then show this result to be robust to HIV duration, cellular composition, and general methylome disorder. Finally we show a pattern of hypomethylation in HIV+ individuals at the HLA locus. Together these results lead to a much-needed better understanding of the epigenetic consequences and gerontological aspects of chronic HIV infection.
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