Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Global Molecular Landscape of Hematopoietic Stem Cells and their Immediate Progeny

ABSTRACT: The Global Molecular Landscape of Hematopoietic Stem Cells and their Immediate Progeny

PROVIDER: PRJEB5296 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR420370_1.fastq.gz	Fastqsanger.gz
	ERR420370_2.fastq.gz	Fastqsanger.gz
	ERR420371_1.fastq.gz	Fastqsanger.gz
	ERR420371_2.fastq.gz	Fastqsanger.gz
	ERR420372_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

The Global Molecular Landscape of Hematopoietic Stem Cells and their Immediate Progeny

Project description:Hematopoietic stem cells (HSC) possess life-long self-renewal activity and generate a series of multipotent progenitors that differentiate into lineage-committed progenitors and subsequently mature cells. Recently, functionally distinct stem and progenitor cell types have been identified, however, a systems-wide understanding of the underlying gene regulation is lacking. Here, we present the global transcriptome of ex vivo isolated mouse multipotent hematopoietic stem cells (HSC) and multipotent progenitor cells (MPP1-MPP4) as revealed by next-generation sequencing (RNA-seq). A related high-throughput study with DNA methylome data was also conducted, with data deposited at NCBI Gene Expression Omnibus, under accession GSE52709 ( http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE52709 ). An imported copy of the methylome data set can also be found at ArrayExpress: http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52709.

2014-08-21 | E-MTAB-2262 | biostudies-arrayexpress

The complete methylome of hematopoietic stem cells and their immediate progeny

Project description:Hematopoietic stem cells (HSCs) constitute a rare cell population in bone-marrow and are capable of live-long self-renewal and production of all mature blood cell types. Cell differentiation processes are governed by epigenetic mechanisms whose study during early differentiation steps will provide insights into stem cell function and differentiation. We performed whole-genome bisulfite sequencing on HSCs and their immediate progeny, namely three different multipotent progenitor subpopulations (MPP1, MPP2, and MPP). Whole-genome bisulfite sequencing of hematopoietic stem cells (HSCs) and 3 different multipotent progenitor subpopulations (MPP). Three independent biological replicates each were analyzed.

2014-08-25 | E-GEOD-52709 | biostudies-arrayexpress

The complete methylome of hematopoietic stem cells and their immediate progeny

2014-08-25 | GSE52709 | GEO

The Global Molecular Landscape of dormant Hematopoietic Stem Cells

Project description:The Global Molecular Landscape of dormant Hematopoietic Stem Cells

| PRJEB20543 | ENA

The Global Molecular Landscape of dormant Hematopoietic Stem Cells

Project description:Rare dormant hematopoietic stem cells (dHSCs) reside at the top of the blood hierarchy harboring the highest long-term reconstitution capacity. However, no markers exist to prospectively identify dHSCs and their molecular identity, as well as the mechanism leading to their activation remains poorly understood. Here, we present the global transcriptome of ex vivo isolated mouse multipotent hematopoietic stem cells (HSCs) and dHSCs at the single cell level.

2017-05-18 | E-MTAB-4547 | biostudies-arrayexpress

Immediate response of hematopoietic stem cells to low doses of Î³-irradiation

Project description:Analysis of highly purified long-term hematopoietic stem cells (LT-HSCs) 2 hours after irradiation at 0Gy, 0.02Gy and 2.5Gy. Results provide insight into the molecular mechanisms underlying LT-HSCs immediate response to low doses of Î³-irradiation compared to high doses. Three samples were analyzed and correlated with the control group (0Gy).

2016-02-26 | E-GEOD-66374 | biostudies-arrayexpress

Immediate response of hematopoietic stem cells to low doses of γ-irradiation

2016-02-26 | GSE66374 | GEO

Hematopoietic Fingerprints: an expression database of stem cells and their progeny

Project description:Hematopoietic stem cells (HSC) continuously regenerate a complete hematologic and immune system. Very few genes that regulate this process have yet been identified. In order to identify factors governing differentiation, we have compared the transcriptome of highly purified HSC with their differentiated progeny, including erythrocytes, granulocytes, monocytes, NK cells, activated and naïve T-cells, and B-cells. Chromosomal analysis revealed that HSC were more transcriptionally active than other cell types across most chromosomes. Each lineage expressed ~100 to 400 genes uniquely, including many previously uncharacterized genes. Overexpression of two fingerprint genes resulted in a significant bias in differentiation indicating a role in cell fate determination, demonstrating the utility of these data for modulation of specific cell types. Keywords: Hematopoietic cells, stem cells, wild type cells, Mus musculus

2007-11-21 | GSE6506 | GEO

Human Cancer-Targeted Immunity via Transgenic Hematopoietic Stem Cell Progeny

Project description:Human Cancer-Targeted Immunity via Transgenic Hematopoietic Stem Cell Progeny

| PRJNA1214422 | ENA

Human Cancer-Targeted Immunity via Transgenic Hematopoietic Stem Cell Progeny

Project description:Human Cancer-Targeted Immunity via Transgenic Hematopoietic Stem Cell Progeny

| PRJNA1214421 | ENA