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ABSTRACT: EMG produced TPA metagenomics assembly of PRJNA838940 data set (Metagenomic sequencing of colon contents from gnotobiotic mice harboring the altered Schaedler flora).

PROVIDER: PRJEB56896 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR19241959.fasta.gz	Fasta.gz
	SRR19241958.fasta.gz	Fasta.gz

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Similar Datasets

Project description:Metagenomic sequencing of colon contents from gnotobiotic mice harboring the altered Schaedler flora

| PRJNA838940 | ENA

Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience.

Project description:The gut microbiome consists of trillions of bacteria, fungi, and viruses that inhabit the digestive tract. These communities are sensitive to disruption from environmental exposures ranging from diet changes to illness. Disruption of the community of lactic acid producing bacteria, Lactobaccillacea, has been well documented in mood disorders and stress exposure. In fact, oral supplement with many Lactobacillus species can ameliorate these effects, preventing depression- and anxiety-like behavior. Here, we utilize a gnotobiotic mouse colonized with the Altered Schaedler Flora to remove the two native species of Lactobaccillacea. Using this novel microbial community, we found that the Lactobacillus species themselves, and not the disrupted microbial communities are protective from environmental stressors. Further, we determine that Lactobaccillacea are maintaining homeostatic IFNγ levels which are mediating these behavioral and circuit level responses. By utilizing the Altered Schaedler Flora, we have gained new insight into how probiotics influence behavior and provide novel methods to study potential therapies to treat mood disorders.

2023-08-22 | GSE241110 | GEO

Project description:16S rRNA gene Amplicon Sequencing of gnotobiotic mice harboring the Altered Schaedler Flora (ASF)

| PRJNA844334 | ENA

Project description:AOM/DSS model of colitis associated cancer in immunocompetent gnotobiotic mice harboring the altered Schaedler flora

| PRJNA772742 | ENA

Project description:WGS of Escherichia coli LF82 isolated from gnotbiotic mice harboring the altered Schaedler flora

| PRJNA912691 | ENA

Project description:EMG produced TPA metagenomics assembly of PRJNA193217 data set (Chicken cecal contents Metagenome).

| PRJEB41355 | ENA

Rattus rattus breed:LewF344F1

Project description:Colonization with Altered Schaedler Flora Modifies the Physiology and Adenoma Phenotype in a Preclinical Rat Model of Colon Cancer

| PRJNA490292 | ENA

Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans

Project description:Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, plus in vitro studies, revealed liberation of N-methylserotonin from orange fibers by human gut microbiota members including Bacteroides ovatus. Functional genomic analyses of B. ovatus strains grown under permissive and non-permissive N-methylserotonin 'mining' conditions revealed polysaccharide utilization loci that target pectins whose expression correlate with strain-specific liberation of this compound. N-methylserotonin, orally administered to germ-free mice, reduced adiposity, altered liver glycogenesis, shortened gut transit time, and changed expression of genes that regulate circadian rhythm in the liver and colon. In human studies, dose-dependent, orange-fiber-specific fecal accumulation of N-methylserotonin positively correlated with levels of microbiome genes encoding enzymes that digest pectic glycans. Identifying this type of microbial mining activity has potential therapeutic implications.

2022-07-28 | MTBLS2331 | MetaboLights

Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience.

Project description:Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience.

| PRJNA1006411 | ENA

B.thetaiotaomicron mono-association versus B. thetaiotaomicron co-colonization with B. longum, PR chow, B6

Project description:Genome wide transcriptional comparison of B. thetaiotaomicron mono-association vs. B. thetaiotaomicron bi-association with B. longum. Cecal populations from 10d colonizations with b6 gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Total RNA was prepared from cecal contents of 10 day associated gnotobiotic mice and hybridized to B. thetaiotaomicron/B. longum GeneChips.

2010-07-01 | E-GEOD-5866 | biostudies-arrayexpress

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