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Rattus rattus breed:LewF344F1

ABSTRACT: Colonization with Altered Schaedler Flora Modifies the Physiology and Adenoma Phenotype in a Preclinical Rat Model of Colon Cancer

PROVIDER: PRJNA490292 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7819520_1.fastq.gz	Fastqsanger.gz
	SRR7819520_2.fastq.gz	Fastqsanger.gz
	SRR7819530_1.fastq.gz	Fastqsanger.gz
	SRR7819530_2.fastq.gz	Fastqsanger.gz
	SRR7819540_1.fastq.gz	Fastqsanger.gz

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Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience.

Project description:The gut microbiome consists of trillions of bacteria, fungi, and viruses that inhabit the digestive tract. These communities are sensitive to disruption from environmental exposures ranging from diet changes to illness. Disruption of the community of lactic acid producing bacteria, Lactobaccillacea, has been well documented in mood disorders and stress exposure. In fact, oral supplement with many Lactobacillus species can ameliorate these effects, preventing depression- and anxiety-like behavior. Here, we utilize a gnotobiotic mouse colonized with the Altered Schaedler Flora to remove the two native species of Lactobaccillacea. Using this novel microbial community, we found that the Lactobacillus species themselves, and not the disrupted microbial communities are protective from environmental stressors. Further, we determine that Lactobaccillacea are maintaining homeostatic IFNγ levels which are mediating these behavioral and circuit level responses. By utilizing the Altered Schaedler Flora, we have gained new insight into how probiotics influence behavior and provide novel methods to study potential therapies to treat mood disorders.

2023-08-22 | GSE241110 | GEO

Project description:Metagenomic sequencing of colon contents from gnotobiotic mice harboring the altered Schaedler flora

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Project description:WGS of Escherichia coli LF82 isolated from gnotbiotic mice harboring the altered Schaedler flora

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Project description:16S rRNA gene Amplicon Sequencing of gnotobiotic mice harboring the Altered Schaedler Flora (ASF)

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Project description:Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience.

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Project description:AOM/DSS model of colitis associated cancer in immunocompetent gnotobiotic mice harboring the altered Schaedler flora

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Project description:EMG produced TPA metagenomics assembly of PRJNA838940 data set (Metagenomic sequencing of colon contents from gnotobiotic mice harboring the altered Schaedler flora).

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