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The prevalence of multidrug resistance Enterobacteriaceae among neonates at Farwaniya hospital in Kuwait

ABSTRACT: The prevalence of multidrug resistance Enterobacteriaceae among neonates at Farwaniya hospital in Kuwait

PROVIDER: PRJEB57325 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10468513.fastq.gz	Fastqsanger.gz
	ERR10468514.fastq.gz	Fastqsanger.gz
	ERR10468515.fastq.gz	Fastqsanger.gz
	ERR10468516.fastq.gz	Fastqsanger.gz
	ERR10468517.fastq.gz	Fastqsanger.gz

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The Prevalence of Multidrug-Resistant <i>Enterobacteriaceae</i> among Neonates in Kuwait.

Project description:Increasing numbers of neonates with serious bacterial infections, due to resistant bacteria, are associated with considerable morbidity and mortality rates. The aim of this study was to evaluate the prevalence of drug-resistant Enterobacteriaceae in the neonatal population and their mothers in Farwaniya Hospital in Kuwait and to determine the basis of resistance. Rectal screening swabs were taken from 242 mothers and 242 neonates in labor rooms and wards. Identification and sensitivity testing were performed using the VITEK® 2 system. Each isolate flagged with any resistance was subjected to the E-test susceptibility method. The detection of resistance genes was performed by PCR, and the Sanger sequencing method was used to identify mutations. Among 168 samples tested by the E-test method, no MDR Enterobacteriaceae were detected among the neonates, while 12 (13.6%) isolates from the mothers' samples were MDR. ESBL, aminoglycosides, fluoroquinolones, and folate pathway inhibitor resistance genes were detected, while beta-lactam-beta-lactamase inhibitor combinations, carbapenems, and tigecycline resistance genes were not. Our results showed that the prevalence of antibiotic resistance in Enterobacteriaceae obtained from neonates in Kuwait is low, and this is encouraging. Furthermore, it is possible to conclude that neonates are acquiring resistance mostly from the environment and after birth but not from their mothers.

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