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IGAS and scarlet fever upsurge in the UK 2022-2023

ABSTRACT: Rapid expansion and international spread of M1UK in the post-pandemic upsurge of Streptococcus pyogenes infections in United Kingdom

PROVIDER: PRJEB68199 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR12370800_1.fastq.gz	Fastqsanger.gz
	ERR12370800_2.fastq.gz	Fastqsanger.gz
	ERR12370900_1.fastq.gz	Fastqsanger.gz
	ERR12370900_2.fastq.gz	Fastqsanger.gz
	ERR12371000_1.fastq.gz	Fastqsanger.gz

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Project description:At the end of 2022 into early 2023, the UK Health Security Agency reported unusually high levels of scarlet fever and invasive disease caused by Streptococcus pyogenes (StrepA or group A Streptococcus). During this time, we collected and genome-sequenced 341 non-invasive throat and skin S. pyogenes isolates identified during routine clinical diagnostic testing in Sheffield, a large UK city. We compared the data with that obtained from a similar collection of 165 isolates from 2016 to 2017. Numbers of throat-associated isolates collected peaked in early December 2022, reflecting the national scarlet fever upsurge, while skin infections peaked later in December. The most common emm-types in 2022-2023 were emm1 (28.7 %), emm12 (24.9 %) and emm22 (7.7 %) in throat and emm1 (22 %), emm12 (10 %), emm76 (18 %) and emm49 (7 %) in skin. While all emm1 isolates were the M1UK lineage, the comparison with 2016-2017 revealed diverse lineages in other emm-types, including emm12, and emergent lineages within other types including a new acapsular emm75 lineage, demonstrating that the upsurge was not completely driven by a single genotype. The analysis of the capsule locus predicted that only 51 % of throat isolates would produce capsule compared with 78% of skin isolates. Ninety per cent of throat isolates were also predicted to have high NADase and streptolysin O (SLO) expression, based on the promoter sequence, compared with only 56% of skin isolates. Our study has highlighted the value in analysis of non-invasive isolates to characterize tissue tropisms, as well as changing strain diversity and emerging genomic features which may have implications for spillover into invasive disease and future S. pyogenes upsurges.

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