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IlArePhra

ABSTRACT: Arenostola phragmitidis (fen wainscot), genomic and transcriptomic data

PROVIDER: PRJEB89311 | ENA |

REPOSITORIES: ENA

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Dataset's files

Source:

			Action	DRS
	ERR14986917_1.fastq.gz	Fastqsanger.gz
	ERR14986917_2.fastq.gz	Fastqsanger.gz
	ERR14986746_1.fastq.gz	Fastqsanger.gz
	ERR14986746_2.fastq.gz	Fastqsanger.gz
	ERR14986747_1.fastq.gz	Fastqsanger.gz

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ilArePhra

Project description:Arenostola phragmitidis (fen wainscot)

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Identification of flap structure specific endonuclease 1 as a factor involved in LTM formation of aversive learning

Project description:We proposed that DNA recombination/repair processes play a role in memory formation. Here, we used microarray analysis of rat amygdala genes to identify possible DNA recombination/repair factors involved in memory consolidation of conditioned taste aversion (CTA). Among the genes that showed statistically significant differential expression, we identified fen-1, encoding a flap-structure specific DNA endonuclease. Amygdalar fen-1 mRNA induction was associated to the illness component of CTA, since it could be observed by the pairing of a flavor and gastrointestinal illness, by the illness itself, but not by the presentation of the flavor alone. No CTA related induction of fen-1 expression was observed in the insular cortex. Importantly, functional validation studies demonstrated that amygdalar suppression of fen-1 expression impaired memory consolidation of CTA. Overall, our studies helped identify a new DNA recombination/repair candidate factor involved in memory formation of aversive experiences.

2009-12-30 | GSE11520 | GEO

iyEndPhra

Project description:Endromopoda phragmitidis, iyEndPhra

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Project description:Arenostola phragmitidis overview

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