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Salivary microbiota and type 1 diabetes mellitus

ABSTRACT: Salivary microbiota in children with and without type 1 diabetes mellitus: A one-year Follow-up Study

PROVIDER: PRJEB89884 | ENA |

REPOSITORIES: ENA

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EFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

Project description:<p>INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metabolic profiling offers a useful tool to identify novel disease biomarkers and metabolic alterations before clinical manifestations. OBJECTIVE: This study aimed to identify early metabolic alterations and potential biomarkers predictive of T2DM in a cohort of healthy normoglycemic participants over a six-year follow-up. METHODS: A cohort of 94 healthy participants, both men and women aged 18-40, was studied at six-year intervals. Clinical and biochemical parameters were measured, and LC/MS/MS-based untargeted metabolomics analysis of plasma was performed at baseline and follow-up. RESULTS: At follow-up, 9 participants developed T2DM, 51 had prediabetes and 34 remained normoglycemic. Increasing insulin resistance and elevated future T2DM risk were observed in both the Prediabetes and Normal groups. Metabolomics analysis identified Phosphatidylethanolamine (PE) (20:3_18:0), 3beta,7alpha-Dihydroxy-5-cholestenoate and Tridecanoic acid – as having good predictive capacity for future T2DM risk at baseline with alterations in Phosphatidylethanolamine (PE) (20:3_18:0), and Tridecanoic acid persisting at follow-up. CONCLUSION: The study highlights the potential of metabolomics in identifying early metabolic predictors of T2DM, emphasizing the need for early interventions in healthy normoglycemic young adults.</p>

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Project description:This longitudinal study analyzed whole-blood DNA methylation profiles in adults classified as normoglycemic, prediabetic, or type 2 diabetes mellitus (T2DM). Oxford Nanopore PromethION long-read sequencing (PCR-free ligation preparation) was used to generate genome-wide CpG methylation data at baseline and at six-year follow-up. The dataset includes raw nanopore reads (available in SRA) and processed methylation outputs, including CpG-wise differential methylation, methylation summaries, promoter/CpG island annotation, HOMER functional annotation, and gene–pathway mapping

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