Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

WOMEN PAIN MEMORY STUDY 2025-may

ABSTRACT: Relations between the gut-brain axis: New perspectives on microbiota and its role in the pathophysiology of fibromyalgia

PROVIDER: PRJEB89963 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR15090600_1.fastq.gz	Fastqsanger.gz
	ERR15090600_2.fastq.gz	Fastqsanger.gz
	ERR15090601_1.fastq.gz	Fastqsanger.gz
	ERR15090601_2.fastq.gz	Fastqsanger.gz
	ERR15090602_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 160

Similar Datasets

CBFM

Project description:Relations between the gut-brain axis: New perspectives on microbiota and its role in the pathophysiology of fibromyalgia

| PRJEB90036 | ENA

Identification of unique genomic signatures in patients with fibromyalgia and chronic pain

Project description:Fibromyalgia is a chronic pain syndrome characterized by widespread pain. The pathophysiology of fibromyalgia is not clearly understood and there are no specific biomarkers available for accurate diagnosis. Here we define genomic signatures using high throughput RNA sequencing on 96 fibromyalgia and 93 matched controls. Our findings revealed two major fibromyalgia-associated expression signatures. The first group included 44 patients with a signature enriched for gene expression associated with extracellular matrix and downregulation of RhoGDI signaling pathway. The second group included 31 patients and showed a profound reduction in the expression of inflammatory mediators with an increased expression of genes involved in the CLEAR signaling pathway. These results suggest defective tissue homeostasis associated with the extra-cellular matrix and cellular program that regulates lysosomal biogenesis and participates in macromolecule clearance in fibromyalgia. Further elucidation of these pathways will lead to development of accurate diagnostic markers, and effective therapeutic options for fibromyalgia.

2024-02-21 | GSE221921 | GEO

DNA methylation analysis in women with fibromyalgia

Project description:FM is a complex syndrome with physiological, genetics and environmental factors involved. It can present changes in functional neuroimaging, in cortical excitability measurements performed by transcranial magnetic stimulation and in grey matter density. Similarly, it has been shown that patients with FM have abnormal autonomic control, inflammatory profile and dysfunctional hypothalamic–pituitary–adrenal axis leading to disruptive sleep and fatigue. We characterized clinical and neurophysiological parameters and peripheral blood DNA methylation profiles of patients with FM and compared them to sex and age matched healthy controls. We hypothesized that these exploratory analyses could provide mechanistic insights into the pathophysiology of FM and possibly contribute to the future development of biological markers of diagnosis.We showed that patients with fibromyalgia have different (mainly hypo-) methylated CpG sites related to genes implicated in immune system and response to external stress pathways and that this methylation profile is related to a dysfunctional connectivity in pain network, adding evidence to consider fibromyalgia as a DOHAD disorder.

2017-08-10 | GSE85506 | GEO

Serum proteomics of sng- and pain-trend fibromyalgia patients

Project description:Fibromyalgia (FM) is a chronic pain condition and consists of widespread pain with similarities to neuropathic pain in clinical findings, pathophysiology, and neuropharmacology. Its mechanisms are poorly understood and a lack of effective biomarkers for diagnosis and onset prediction. This study aimed to identify the metabolites to characterize pain and sngception (Sng) in FM.

2022-08-12 | PXD022886 | Pride

Conserved small RNA networks link inflammation to pain signaling in mice and men

Project description:Inflammation may lead to pain, but the underlying mechanisms remain unclear. Here, we identify cooperating small non-coding RNA (sncRNA) signatures including microRNAs (miRs) and transfer RNA fragments (tRFs) that may drive inflammatory pain in both acute and chronic settings. Initiating lipopolysaccharide (LPS)-induced inflammation altered ganglion-specific, time-dependent miRs and tRFs in murine trigeminal (sensory) and superior cervical (sympathetic) ganglia. Indicating conserved pain-related regulatory elements, many of those changes overlapped with those observed in fibromyalgia syndrome (FMS) patient-derived blood cells and keratinocytes. Moreover, cross-species integrative analyses revealed two oppositely correlated sncRNA clusters whose expression ratios distinguished inflammatory from non-inflammatory states and increased during human nociceptor differentiation. Further suggesting functional roles in pain modulation, these pain-related sncRNAs targeted distinct long RNAs expressed in pain- and cholinergic-related states. Importantly, these sncRNAs and their associated transcripts were validated in datasets from both a murine spinal nerve injury model and synovium samples from osteoarthritis patients with varying pain intensities. Our findings reveal that specific miRs and tRFs act as conserved regulators of nociceptive signaling across species, tissues and pain modalities. Further, this work reveals new understanding of the molecular underpinnings of pain and highlights the notion that mammalian pain- and cholinergic-related sncRNAs actively contribute to the shift from inflammation to peripheral nervous system pain, including fibromyalgia pain.

2025-08-24 | GSE303093 | GEO

Human herpesvirus-6B infection and alterations of gut microbiome in patients with fibromyalgia: a pilot study

Project description:Fibromyalgia and gut microbiome

| PRJEB80379 | ENA

Circulating proteins in the plasma of pregnant women with early and late onset preeclampsia versus healthy pregnant women

Project description:Preeclampsia (PE) is a multifactorial disease with a complex pathophysiology and no specific treatment currently available. Therefore, investigating altered pathways, proteins, and metabolites, as well as identifying potential biomarkers and therapeutic targets, becomes essential. Thus, the objective of this work is to identify the proteins altered or involved in the pathophysiology of PE.

2025-02-06 | MSV000097061 | MassIVE

Fibromyalgia microbiome study

Project description:Fibromyalgia Microbiome Analysis: data from Ebiomedicine paper "Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia" by Clos-Garcia, M. et al.

| PRJEB27227 | ENA

SIRT in 2025.

Project description:Selective internal radiation therapy represents an endovascular treatment option for patients with primary liver malignancies, in different clinical stages. Potential applications of this treatment are in early-stage hepatocellular carcinoma, as a curative option, or in combination with systemic treatments in intermediate and advanced-stages. This review, based on existing literature and ongoing trials, will focus on the future of this treatment in patients with hepatocellular carcinoma, in combination with systemic treatments, or with the use of new devices and technological developments; it will also describe new potential future indications and structural and organizational perspectives.

| S-EPMC9360734 | biostudies-literature

The Correlation among Serum Proteomics and Clinical Profiles in Fibromyalgia Women

Project description:Fibromyalgia (FM) is a multifactorial disorder with unclear pathomechanism. There’s an urgent need to explore the potential biomarkers and correlate with the clinical profiles in FM to facilitate the specific management of FM patients. This study aims to 1) investigate the differential serum proteome profiles in patients with FM and healthy controls and 2) explore the correlation between serum proteome and clinical profiles in FM patients

2020-05-17 | PXD013905 | JPOST Repository

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data