Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach

ABSTRACT: Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach

PROVIDER: PRJEB94531 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach

Project description:High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolbox of technologies to inform on bioactivity.

2025-09-15 | E-MTAB-15266 | biostudies-arrayexpress

An Advancement in Developmental and Reproductive Toxicity (DART) Risk Assessment: Evaluation of a Bioactivity and Exposure-Based NAM Toolbox

2025-09-15 | E-MTAB-15274 | biostudies-arrayexpress

Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach.

Project description: Not available

| S-EPMC11879040 | biostudies-literature

An Advancement in Developmental and Reproductive Toxicity (DART) Risk Assessment: Evaluation of a Bioactivity and Exposure-Based NAM Toolbox

Project description:An Advancement in Developmental and Reproductive Toxicity (DART) Risk Assessment: Evaluation of a Bioactivity and Exposure-Based NAM Toolbox

| PRJEB94457 | ENA

Flavor Toolbox Assessment

Project description:The toxicity and potential associated molecular mechanism of a mixture of representative flavors, compared to a matrix containing propylene glicol (PG), vegetable glycerin (VG) and nicotine, were investigated with human bronchial epithelial cells using high-throughput screening and whole transcriptomics analysis.

2017-05-05 | E-MTAB-5317 | biostudies-arrayexpress

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

Project description:Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

| PRJNA1206072 | ENA

Transcriptome profiling of human myogenic progenitors following treatment with nicotinamide (NAM) or pyridoxine (PN) or the combination (NAM/PN).

Project description:Working with primary human myogenic progenitors (hMPs), we developed a high-content screen to discover molecules that enhanced myogenic function and identified NAM and PN as modulators of myogenic proliferation and differentiation. We characterized genome-wide expression profiles of NAM-, PN-treated and NAM/PN-treated hMPs with the goal to uncover the mechanisms of action of NAM and PN and the potential additivity from the combination at the molecular level in hMPs.

2024-11-18 | GSE264285 | GEO

A rapid assessment model for liver toxicity of macrolides and an integrative evaluation for azithromycin impurities

Project description:we report an assessment of macrolides related liver toxicity by using ADMET prediction, molecular docking, structure-toxicity relationship and experimental verification via detecting the c-fos gene expression in liver cells.We employed the model to virtual screening of azithromycin impurities with high hepatotoxicity, and then experimental confirmed by liver toxicity in zebrafish, and c-fos gene expression.

2022-03-31 | GSE195903 | GEO

Are Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow

2025-09-15 | E-MTAB-15258 | biostudies-arrayexpress

Effect of NAM on the TGFβ1-induced hESC-derived corneal endothelial progenitor cells

Project description:To further explore the effect of NAM on the TGFβ1-induced hESC-derived corneal endothelial progenitor cells, we have employed whole RNA microarray expression profiling as a discovery platform to identify genes and mechanism of NAM on the EnMT and senescence. hESC-derived endothelial progenotors were culured under 30ng/ml TGFβ1 with or without 50 mM NAM. The cultures were incubated for 72 hours at 37 ºC in a humidified incubator with 5% CO2.

2022-01-05 | GSE183786 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data