Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA100621 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:The absence of the Rb tumor suppressor gene changes levels/activities of transcription factors (e.g., E2F and p53) which alter gene expression patterns, related to cell cycle control and cellular response to DNA damage. Cisplatin is a genotoxic chemotherapeutic agent and wildtype or Rb null cells have different sensitivities to cisplatin-induced cytotoxicity. We used microarrays to compare global profiles of gene expression and distinct responses of wildtype and Rb null MEFs in response to cisplatin. Experiment Overall Design: Primary wildtype or Rb null MEFs were generated from embryos at embryonic day 13.5 and cultured to passage 2. Wildtype or Rb null MEFs were either untreated or treated with 16 microM cisplatin for 24 hours prior to harvest and RNA extraction. Four different RNA samples (wildtype or Rb-/- MEFs, untreated or cisplatin-treated) were used for hybridization in triplate to Affimatrix Chips. Then, the total of 12 hybridizations were divided into 4 subseries: UT-Rb, UT-WT, CP-Rb, CP-Wt, and each subseries contained three samples (hybridization 1-3 or a-c).
2008-06-14 | E-GEOD-6206 | biostudies-arrayexpress
Project description:Expression data from untreated and Aza treated AML3 cells
2025-01-24 | E-GEOD-55123 | ExpressionAtlas
Project description:The absence of the Rb tumor suppressor gene changes levels/activities of transcription factors (e.g., E2F and p53) which alter gene expression patterns, related to cell cycle control and cellular response to DNA damage. Cisplatin is a genotoxic chemotherapeutic agent and wildtype or Rb null cells have different sensitivities to cisplatin-induced cytotoxicity. We used microarrays to compare global profiles of gene expression and distinct responses of wildtype and Rb null MEFs in response to cisplatin. Keywords: genotype and cisplatin treatment
2007-09-01 | GSE6206 | GEO
Project description:Expression data from rosiglitazone treated, rosiglitazone withdrawal and untreated control Zucker Diabetic Fatty rats.
2015-07-07 | E-GEOD-30147 | ExpressionAtlas
Project description:Gene expression data of untreated and RA-treated wild type and RXR-deficient mice liver
2015-07-27 | E-GEOD-50028 | ExpressionAtlas
Project description:Expression data from wild-type or Rb mutant MEFs
| PRJNA307691 | ENA
Project description:Whole genome expression data comparison between WT and Cebpg-/- MEFs.
2015-07-17 | E-GEOD-47777 | ExpressionAtlas
Project description:Expression data from wildtype and Rb-/- fetal liver at e12.5
| PRJNA99231 | ENA
Project description:Expression data from miR-92 over-expressing R26MER/MER mouse embryonic fibroblast (MEFs)
2015-07-31 | E-GEOD-53225 | ExpressionAtlas
Project description:Expression data from mouse liver treated with metformin
2015-09-28 | E-GEOD-35961 | ExpressionAtlas