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Transcriptomic profile of IEC4.1 cells treated with an ASO to lncRNA XR_001779380 in response to IFN-gamma

ABSTRACT: Transcriptomic profile of IEC4.1 cells treated with an ASO to lncRNA XR_001779380 in response to IFN-gamma

PROVIDER: PRJNA1028577 | ENA |

REPOSITORIES: ENA

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			Action	DRS
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	SRR26398259_1.fastq.gz	Fastqsanger.gz
	SRR26398259_2.fastq.gz	Fastqsanger.gz
	SRR26398262_1.fastq.gz	Fastqsanger.gz
	SRR26398262_2.fastq.gz	Fastqsanger.gz

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Transcriptomic profile of IEC4.1 cells treated with an ASO to lncRNA XR_001779380 in response to IFN-gamma

Project description:LncRNAs may play an important role in intestinal epithelial cell autonomous defense against microbial infection. Our previous study showed that lncRNA XR_001779380 can interact with Prdm1 to modulate gene transcriuption in intestinal epithelial cells and may regualte IFN-gamma-stimulated gene transcription. Here we designed an antisense oligos-morpholine (ASO4) targeting the sequence of lncRNA XR_001779380 to interfere with its interaction with PRDM1. Murine intestinal epithelial cells (IEC4.1 cells) were treated with ASO4 or a standard control ASO-morpholine (ST) for 24h, followed by exposure to IFN-gamma (1 ng/ml) for 4 hours. Then total RNA was collected for sequencing via DNBSEQ platform to obtain a comprehensive view of the transcriptome.

2025-05-29 | GSE245478 | GEO

Transcriptome Profile of IEC4.1 cells deficient with Prdm1 in response to IFN-gamma

Project description:This study is to investigate the potential role of Prdm1 in murine intestinal epithelial cells (IEC4.1 cells) in response to IFN gamma stimulation. Prdm1 was knocked down in IEC4.1 cells by using a CRISPR/Cas9 approach. Wild type IEC4.1 cells were used as control (Ctrl). Cells were treated with or without mouse IFN gamma (1ng/ml for 4hrs). Then total RNA was collected for sequencing via DNBSEQ platform to obtain a comprehensive view of the transcriptome.

2025-05-30 | GSE245345 | GEO

Transcriptomic profile of IEC4.1 cells treated with an siRNA to lncRNA NR_126553 (Nostril) in response to IFN-gamma protein (IFNγ)

Project description:This study is to investigate the potential impact of an lncRNA NR_126553 (Nostril) in murine intestinal epithelial cells (IEC4.1 cells) in response to IFN-gamma protein (IFNγ) stimulation. NR_126553 (Nostril) was knocked down by using a pool of gene specific siRNA (SiNostril). Cells treated with scramble non-specific siRNA were used as control (siNegative control). After siRNA transfection 24h, cells were treated with or without mouse IFNγ (1ng/ml for 4hrs). Then total RNA was collected for sequencing via DNBSEQ platform to obtain a comprehensive view of the transcriptome.

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Next Generation Sequencing Analysis of Transcriptome Profile in CRISPR/Cas9 U90926KO IEC4.1 Cells Treated with IFN-gamma protein (IFNγ)

Project description:Interferon-gamma protein (IFNγ) plays a key role in intestinal epithelial cell-autonomous defense against microbial infection. The underlying mechansims of host immune regulation remains obscure and increasing evidence has shown long non coding RNAs (lncRNAs) can regulating gene expression at both the transcriptional and posttranscitpional levels. In the current study, we analyzed the transcriptome of murine intestinal epithelial cells (IEC4.1 cells) or stable CRISPR/cas9 U90926KO IEC4.1 cells following treatment with IFNγ to identify potential immune gene tragets of this lncRNA. Total RNA was collected for the genome-wide analysis, for sequencing using DNBSEQ platform.

2025-09-09 | GSE245533 | GEO

Transcriptome Profile of IEC4.1 cells deficient with Prdm1 in response to IFN-gamma

Project description:Transcriptome Profile of IEC4.1 cells deficient with Prdm1 in response to IFN-gamma

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Transcriptomic profile of IEC4.1 cells treated with an siRNA to lncRNA NR_126553 (Nostril) in response to IFN-gamma protein (IFNγ)

Project description:Transcriptomic profile of IEC4.1 cells treated with an siRNA to lncRNA NR_126553 (Nostril) in response to IFN-gamma protein (IFNγ)

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human ESC-MSCs: IFN-γ-nontreated, IFN-γ-treated for 1 day, IFN-γ-treated for 3 days

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human ESC-MSCs: IFN-γ-nontreated, IFN-γ-treated for 1 day, IFN-γ-treated for 3 days

Project description:human ESC-MSCs: IFN-γ-nontreated, IFN-γ-treated for 1 day, IFN-γ-treated for 3 days

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Project description:IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages Keywords: repeat sample

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Transcription profiling of IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages

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