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ABSTRACT: RNA-seq on Fructus Psoraleae-treated mice liver

PROVIDER: PRJNA1035563 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26667622_1.fastq.gz	Fastqsanger.gz
	SRR26667622_2.fastq.gz	Fastqsanger.gz
	SRR26667623_1.fastq.gz	Fastqsanger.gz
	SRR26667623_2.fastq.gz	Fastqsanger.gz
	SRR26667624_1.fastq.gz	Fastqsanger.gz

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Gene expression profile at single cell level of cells from healthy and BV-induced murine liver.

Project description:Bavachin (BV), a therapeutic phytoestrogen in Fructus Psoraleae (FP), has been used in various diseases. However, the molecular mechanism of BV hepatotoxicity reported by many studies remains unclear. Here, we used single cell RNA sequencing (scRNA-seq) to explore the early cytotoxicity induced by BV in the liver.

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Project description:Molecular mechanisms of Psoraleae Fructus-induced liver injury: insights from computational toxicology and transcriptomics analysis

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Project description:Transcriptome sequencing of mice treated with Chebulae Fructus hydrosoluble extract ethyl acetate fraction and water were performed, and the gene expression profiles were compared.

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Project description:Kidney-yang deficiency syndrome (KYDS) is a metabolic disease caused by neuroendocrine disorders often accompanied by abnormal liver function. Psoraleae Fructus (BGZ) is widely used to treat KYDS in China, but it is unclear whether BGZ plays a therapeutic role in regulating liver function. Organ index, ALT, AST, and HE staining were used to evaluate the protective effect of BGZ on KYDS in rats, and transcriptomics and metabolomics were employed to screen for potential biomarkers. The results showed that BGZ treatment significantly decreased the levels of ALT and AST, and ameliorated liver pathological damage in KYDS rats. 92 differentially expressed genes (DEGs) and 20 metabolites were significantly disturbed by BGZ in KYDS rats. Integrated analysis of metabolites and DEGs revealed that neuroactive ligand-receptor interaction, cAMP pathway, calcium signaling pathway, and cytokine-cytokine receptor interaction may be the main mechanism of BGZ treatment, and the key targets of the cAMP pathway were confirmed by ELISA and RT-qPCR. In conclusion, the cAMP pathway may be the partial mechanism by which BGZ exerts protective effects on KYDS, and the study results also lay the foundation for more in-depth mechanistic studies and drug-targeted therapy of KYDS in the future.

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