Project description:This SuperSeries is composed of the following subset Series: GSE4453: Androgen receptor coregulators baseline comparisons GSE4454: Androgen receptor-coregulators hormone responsiveness LNCaP / GSF Refer to individual Series
Project description:To decipher the contribution of coregulators to androgen receptor target gene expression, effect of siRNA-mediated silencing of 18 clinically relevant coregulators on bona fide androgen receptor target gene expression was studied.
Project description:KDM1A and KDM7A are Androgen Receptor coregulators. Here siRNAs targeting KDM1A and KDM7A were used to deplete KDM1A and KDM7A in prostate cancer cells and the effect on androgen regulated gene expression and splicing determined.
Project description:KDM1A and KDM7A are Androgen Receptor coregulators. Here the KDM1A and KDM7A inhibitors, namoline and TCE-5002 were used to pharmacologically inhibit KDM1A and KDM7A in prosate cancer cells and the effect on androgen regulated gene expression and splicing determined.
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
