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Placental Privilege: Evidence of Organ Resilience in severe COVID-19

ABSTRACT: Placental Privilege: Evidence of Organ Resilience in severe COVID-19

PROVIDER: PRJNA1047537 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27018900_1.fastq.gz	Fastqsanger.gz
	SRR27018900_2.fastq.gz	Fastqsanger.gz
	SRR27018901_1.fastq.gz	Fastqsanger.gz
	SRR27018901_2.fastq.gz	Fastqsanger.gz
	SRR27018902_1.fastq.gz	Fastqsanger.gz

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Placental Privilege: Evidence of Organ Resilience in severe COVID-19

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Project description:Here we show that ?-catenin mediates pro-resilient and anxiolytic effects in mice in the nucleus accumbens (NAc), a key brain reward region, an effect that is mediated by ?-catenin signaling in D2-type medium spiny neurons (MSNs) specifically. Conversely, blocking ?-catenin function in NAc promotes susceptibility to chronic stress, and we show evidence of robust suppression of ?-catenin transcriptional activity in the NAc both of depressed humans examined postmortem as well as of mice that display a susceptible phenotype after chronic stress, with a converse upregulation in mice that are stress resilient. Using ChIP-seq, we demonstrate a global, genome-wide enrichment of ?-catenin in the NAc of resilient mice, and specifically identify Dicer1—important in small RNA (e.g., microRNA [miRNA]) biogenesis—as a critical ?-catenin target gene involved in mediating a resilient phenotype. Small RNA-seq after excising ?-catenin from the NAc in the context of chronic stress reveals dynamic ?-catenin-dependent miRNA regulation associated with resilience. Control: 2 samples, Resilient: 2 samples, Susceptible: 2 samples; DNA input: 1 sample.

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