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ABSTRACT: RNAs sequencing in perioperative neurocognitive disorders

PROVIDER: PRJNA1054804 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27293218_1.fastq.gz	Fastqsanger.gz
	SRR27293218_2.fastq.gz	Fastqsanger.gz
	SRR27293219_1.fastq.gz	Fastqsanger.gz
	SRR27293219_2.fastq.gz	Fastqsanger.gz
	SRR27293220_1.fastq.gz	Fastqsanger.gz

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Project description:Perioperative neurocognitive disorders

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Expression data from sevoflurane anesthesia treated rat

Project description:Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays.

2020-12-29 | GSE139220 | GEO

Serum proteomics study on cognitive impairment after cardiac valve replacement surgery: A prospective observational study

Project description:The incidence of perioperative neurocognitive disorders (PND) is high, especially after cardiac surgeries, and the underlying mechanisms remain elusive. Here, we conducted a prospective observational study to observe serum proteomics differences in PND patients after cardiac valve replacement surgery.

2024-01-23 | PXD048818 |

Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders

Project description:Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders

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Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

Project description:Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

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Identification and functional analysis of a potential key circRNA in aged mice with perioperative neurocognitive dysfunction

Project description:Perioperative neurocognitive dysfunction (PND) is emerging as a significant complication of surgery in elderly patients. However, the molecular mechanisms of PND are not well known. Here we applied microarray analysis to identify circular RNAs (circRNAs) in hippocampus from a mouse model of PND and control mice. Then, the dysregulated circRNAs were confirmed via quantitative real-time polymerase chain reaction (qRT-PCR). Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to probe the vital functions of dysregulated genes.

2021-08-10 | GSE165798 | GEO

Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders

Project description:Background: Perioperative neurocognitive disorders (PND), a postoperative cognitive dysfunction occurs more often in the elderly. The etiology of PND remains largely elusive. This study aims to understand the etiology in a mouse model with tibial fracture (a surgical trauma), by examining the transcriptome-wide response of hippocampus, a brain region that is tightly associated with memory formation. Methods: Mice at age of 7~8 months were randomly divided into two groups, surgery (tibial fracture) group and control (sham) group. At day (d) 1 after the surgical operation, hippocampal tissues were isolated and then subjected to RNA extraction and RNA sequencing (RNA-seq). Findings: Levels of respiratory complex related genes are significantly decreased in the brain of mice subjected to surgery. Consequently, the activities of multiple respiratory complexes and respiratory chain function is decreased in the hippocampus of mice with surgical operation. Interpretation: We here propose a novel mechanism of mitochondrial dysfunction in PND etiology, and also provide a potential therapeutic target for PND.

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Project description:Identification and functional analysis of circRNA in aged mice with perioperative neurocognitive dysfunction

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Butyrate, but not Propionate, Rescues Maternal Diet-Induced Neurocognitive Deficits in Offspring

Project description:Fiber diet plays a beneficial role in neurocognitive disorders, like dementia and Alzheimer’s Disease. However, insufficient fiber consumption in public increases the concern about public health, particularly about neurocognitive diseases. To survey the association between fiber dietary and neurocognitive performances, mice were subjected to normal-fiber diet or low-fiber diet during gestation, and the neurocognitive functions of the offspring were assessed. We found that maternal low-fiber diet impaired the cognitive functions, and the impairments can be reversed by butyrate, rather than propionate intake. Mechanism studies showed that HDAC4 might become the most potential mediator in butyrate-dependent neurocognitive improvement. Besides, using human maternal serum and paired umbilical cord blood samples, we demonstrated that the SCFA levels in offspring are positively correlated with levels in maternal serum. Those results provide a solid basis for not only maternal fiber diet regulates neurocognitive functions in offspring through altering SCFA levels, but clinical practice in SCFAs-dependent maternal intervention for offspring health.

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