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Characterization of the genes that were regulated by infection with Malassezia furfur

ABSTRACT: Characterization of the genes that were regulated by infection with Malassezia furfur

PROVIDER: PRJNA1084764 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28242571_1.fastq.gz	Fastqsanger.gz
	SRR28242571_2.fastq.gz	Fastqsanger.gz
	SRR28242572_1.fastq.gz	Fastqsanger.gz
	SRR28242572_2.fastq.gz	Fastqsanger.gz
	SRR28242573_1.fastq.gz	Fastqsanger.gz

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Characterization of the genes that were regulated by infection with Malassezia furfur

Project description:In the present study, we investigated the pathogenicity of infection with Malassezia furfur using Caenorhabditis elegans as a model animal. The lifespan of the adult C. elegans infeted with Malassezia furfur was significantly longer than that of uninfected animals (control). Transcriptional profiling comparing infected- and uninfected animals suggested that genes related to the innate immunity were upregulated by infection with Malassezia furfur.

2025-03-06 | GSE260976 | GEO

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Project description:Malassezia furfur Genome sequencing and assembly (CBS7982)

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Project description:Malassezia furfur isolate:CBS14141 Genome sequencing

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Metabolic reconstruction of lipid metabolism of Malassezia

Project description:Malassezia species are lipophilic and lipid dependent yeasts belonging to the human and animal microbiota. Typically, they are isolated from regions rich in sebaceous glands. They have been associated with dermatological diseases such as seborrheic dermatitis, tinea versicolor, atopic dermatitis, and folliculitis. Genome sequences of Malassezia globosa, Malassezia sympodialis, and Malassezia pachydermatis lack genes related to fatty acid synthesis. Here, lipid synthesis pathways of M. furfur, M. pachydermatis, M. globosa, M. sympodialis and an atypical variant of M. furfur were reconstructed using genome data and Constraints Based Reconstruction and Analysis. The metabolic reconstruction allowed us to predict variation in the fluxes of each reaction over the network to satisfy the biomass objective function. Proteomic profiling improved and validated the models through data integration. Results suggest that several mechanisms including steroid and butanoate metabolism explain the yeast’s growth under different lipid conditions. Flux differences were observed in production of riboflavin in M. furfur and the biosynthesis of glycerolipids in the atypical variant of M. furfur and Malassezia sympodialis.

2017-10-02 | PXD004523 | Pride

Malassezia

Project description:Malassezia furfur and Malassezia Pachydermatis genome sequencing and assembly

| PRJNA322049 | ENA

Malassezia

Project description:Malassezia furfur and Malassezia Pachydermatis genome sequencing and assembly

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Physiological and molecular characterization of atypical isolates of Malassezia furfur.

Project description:The species constituting the genus Malassezia are considered to be emergent opportunistic yeasts of great importance. Characterized as lipophilic yeasts, they are found in normal human skin flora and sometimes are associated with different dermatological pathologies. We have isolated seven Malassezia species strains that have a different Tween assimilation pattern from the one typically used to differentiate M. furfur, M. sympodialis, and M. slooffiae from other Malassezia species. In order to characterize these isolates of Malassezia spp., we studied their physiological features and conducted morphological and molecular characterization by PCR-restriction fragment length polymorphism and sequencing of the 26S and 5.8S ribosomal DNA-internal transcribed spacer 2 regions in three strains from healthy individuals, four clinical strains, and eight reference strains. The sequence analysis of the ribosomal region was based on the Blastn algorithm and revealed that the sequences of our isolates were homologous to M. furfur sequences. To support these findings, we carried out phylogenetic analyses to establish the relationship of the isolates to M. furfur and other reported species. All of our results confirm that all seven strains are M. furfur; the atypical assimilation of Tween 80 was found to be a new physiological pattern characteristic of some strains isolated in Colombia.

| S-EPMC2620849 | biostudies-literature

The human pathobiont Malassezia furfur secreted protease MfSAP1 regulates cell dispersal and exacerbates skin inflammation

Project description:Malassezia forms the dominant eukaryotic microbial community on the human skin. The Malassezia genus possesses a repertoire of secretory hydrolytic enzymes involved in protein and lipid metabolism which alter the external cutaneous environment. The exact role of most Malassezia secreted enzymes, including those in interaction with the epithelial surface, are not well characterized. In this study, we compared the expression level of secreted proteases, lipases, phospholipases, and sphingomyelinases of Malassezia globosa in healthy subjects and seborrheic dermatitis or atopic dermatitis patients. We observed upregulated gene expression of the previously characterized secretory aspartyl protease MgSAP1 in both the lesional and non-lesional skin sites of affected compared to healthy subjects. To explore the functional roles of MgSAP1 in skin disease, we generated a knockout mutant of the homologous protease MfSAP1 in the genetically tractable Malassezia furfur. We observed the loss of MfSAP1 resulted in dramatic changes in the cell adhesion and dispersal in both culture and a human 3D reconstituted epidermis model. In a murine model of Malassezia colonization, we further demonstrated MfSAP1 contributes to inflammation as observed by reduced edema and myeloid pustule formation with the knockout mutant versus wildtype. Taken together, we show that this dominant secretory Malassezia aspartyl protease has an important role in enabling a planktonic cellular state that can potentially aid in colonization and additionally as a virulence factor in barrier-compromised skin, further highlighting the importance of considering the contextual relevance when evaluating the functions of secreted microbial enzymes.

2022-11-11 | PXD033336 | JPOST Repository

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