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Transcriptomic changes in lens epithelial cells at 5 days post cataract surgery

ABSTRACT: Transcriptomic changes in lens epithelial cells at 5 days post cataract surgery

PROVIDER: PRJNA1108154 | ENA |

REPOSITORIES: ENA

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Transcriptomic changes in lens epithelial cells at 5 days post cataract surgery

Project description:This trancriptomic analysis describes the gene expression changes observed in wildtype lens epithelial cells (LECs) by 5 days compared to zero hours post cataract surgery

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Changes in gene expression time 0 vs. 1hr post-cataract sugery wounding in the lens

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RNA-seq Analysis of Human Lens Capsules from Donors with and without Cataract Surgery History

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Project description:RNAseq analysis was used to determine the transcriptomic changes associated with regenerative vs. fibrotic repair to lens injury. Using an ex vivo post-cataract surgery model, we can follow two distinct outcomes to lens injury: 1) A regenerative wound healing response that ensues across the cell-denuded lens capsule basement membrane (BM), culminating in wound closure on Day 3 (D3) post-injury. 2) Induction of fibrosis, which occurs when a wound healing response occurs off the lens capsule, termed the extracapsular zone (ECZ), where transition to a fibrotic phenotype occurs on day 3 post-injury. Here, we report the changes in the transcriptome that occur on D1, D2, and D3 post-injury, a period that covers wound healing across the BM and time points prior to (D1, D2) and after induction of the fibrotic phenotype (D3). Our data provides a molecular map for understanding the gene changes associated with navigating normal and pathological outcomes to lens injury.

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Lens epithelial cell transcriptome reprogramming at 48 hours post cataract surgery (PCS) in wild type (WT) and Fibronectin Conditional Knockout (FNcKO) mice

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Project description:Lens epithelial cell transcriptome reprogramming at 24 hours post cataract surgery

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Project description:Transcriptomic changes in lens epithelial cells at 72 hours post cataract surgery

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